Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance
| العنوان: | Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance |
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| المؤلفون: | Jan Gojda, Monika Cahova |
| المصدر: | Biomolecules, Vol 11, Iss 1414, p 1414 (2021) Biomolecules |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Glucose, medicine.medical_specialty, gut microbiome, gut metabolome, Review, Type 2 diabetes, Gut flora, Microbiology, digestive system, Biochemistry, Human gut, Insulin resistance, insulin resistance, Internal medicine, Diabetes mellitus, medicine, Humans, Obesity, branched-chain amino acids, Symbiosis, Molecular Biology, chemistry.chemical_classification, biology, Metabolism, biology.organism_classification, medicine.disease, QR1-502, Gastrointestinal Microbiome, Amino acid, Endocrinology, Diabetes Mellitus, Type 2, chemistry, type 2 diabetes, Amino Acids, Branched-Chain |
| الوصف: | The microbiota-harboring human gut is an exquisitely active ecosystem that has evolved in a constant symbiosis with the human host. It produces numerous compounds depending on its metabolic capacity and substrates availability. Diet is the major source of the substrates that are metabolized to end-products, further serving as signal molecules in the microbiota-host cross-talk. Among these signal molecules, branched-chain amino acids (BCAAs) has gained significant scientific attention. BCAAs are abundant in animal-based dietary sources; they are both produced and degraded by gut microbiota and the host circulating levels are associated with the risk of type 2 diabetes. This review aims to summarize the current knowledge on the complex relationship between gut microbiota and its functional capacity to handle BCAAs as well as the host BCAA metabolism in insulin resistance development. Targeting gut microbiota BCAA metabolism with a dietary modulation could represent a promising approach in the prevention and treatment of insulin resistance related states, such as obesity and diabetes. |
| تدمد: | 2218-273X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6eea4809f69dc55b0e6e5a6b780d3dTest https://doi.org/10.3390/biom11101414Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf6eea4809f69dc55b0e6e5a6b780d3d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2218273X |
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