RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention
| العنوان: | RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention |
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| المؤلفون: | Thomas J. Turbyville, Rebika Shrestha, Trent E. Balius, Andrew G. Stephen, Priyanka Prakash, Que N. Van |
| المصدر: | Biomolecules Biomolecules, Vol 11, Iss 377, p 377 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | membrane dynamics, lcsh:QR1-502, nanoclusters, Review, Biochemistry, lcsh:Microbiology, Nanoclusters, 03 medical and health sciences, dimers, 0302 clinical medicine, Downregulation and upregulation, nonproductive interfaces, Extracellular, Membrane dynamics, Animals, Humans, Molecular Biology, 030304 developmental biology, Molecular switch, 0303 health sciences, Chemistry, Cell Membrane, multimers, Cell biology, Intracellular signal transduction, Membrane, ras Proteins, Nanoparticles, Protein Multimerization, 030217 neurology & neurosurgery, Function (biology), Signal Transduction, RAS |
| الوصف: | RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular switches, turned on by partners that receive extracellular mitogenic signals. In the on-state, they activate intracellular signal transduction cascades. Membrane-bound RAS molecules segregate into multimers, known as nanoclusters. These nanoclusters, held together through weak protein–protein and protein–lipid associations, are highly dynamic and respond to cellular input signals and fluctuations in the local lipid environment. Disruption of RAS nanoclusters results in downregulation of RAS-mediated mitogenic signaling. In this review, we discuss the propensity of RAS proteins to display clustering behavior and the interfaces that are associated with these assemblies. Strategies to therapeutically disrupt nanocluster formation or the stabilization of signaling incompetent RAS complexes are discussed. |
| تدمد: | 2218-273X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e364195b01a60d02ece022d92ad53bTest https://pubmed.ncbi.nlm.nih.gov/33802474Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e8e364195b01a60d02ece022d92ad53b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2218273X |
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