A Critical Regulation of Th17 Cell Responses and Autoimmune Neuro-Inflammation by Ginsenoside Rg3
| العنوان: | A Critical Regulation of Th17 Cell Responses and Autoimmune Neuro-Inflammation by Ginsenoside Rg3 |
|---|---|
| المؤلفون: | Garam Choi, Yeonseok Chung, Young-Jun Park, Hyeongjin Na, Minkyoung Cho |
| المصدر: | Biomolecules Volume 10 Issue 1 Biomolecules, Vol 10, Iss 1, p 122 (2020) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Encephalomyelitis, Autoimmune, Experimental, Ginsenosides, Cell, lcsh:QR1-502, Anti-Inflammatory Agents, chemical and pharmacologic phenomena, medicine.disease_cause, Biochemistry, lcsh:Microbiology, Article, Myelin oligodendrocyte glycoprotein, Autoimmunity, 03 medical and health sciences, Ginseng, 0302 clinical medicine, RAR-related orphan receptor gamma, medicine, Animals, Molecular Biology, Cells, Cultured, Inflammation, biology, EAE, Experimental autoimmune encephalomyelitis, hemic and immune systems, Dendritic cell, respiratory system, medicine.disease, Mice, Inbred C57BL, Rg3, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, biology.protein, Th17 Cells, Female, Tumor necrosis factor alpha, Th17, RORγt, human activities |
| الوصف: | Among diverse helper T-cell subsets, Th17 cells appear to be pathogenic in diverse autoimmune diseases, and thus, targeting Th17 cells could be beneficial for the treatment of the diseases in humans. Ginsenoside Rg3 is one of the most potent components in Korean Red Ginseng (KRG Panax ginseng Meyer) in ameliorating inflammatory responses. However, the role of Rg3 in Th17 cells and Th17-mediated autoimmunity is unclear. We found that Rg3 significantly inhibited the differentiation of Th17 cells from naï ve precursors in a dendritic cell (DC)&ndash T co-culture system. While Rg3 minimally affected the secretion of IL-6, TNF&alpha and IL-12p40 from DCs, it significantly hampered the expression of IL-17A and ROR&gamma t in T cells in a T-cell-intrinsic manner. Moreover, Rg3 alleviated the onset and severity of experimental autoimmune encephalomyelitis (EAE), induced by transferring myelin oligodendrocyte glycoprotein (MOG)-reactive T cells. Our findings demonstrate that Rg3 inhibited Th17 differentiation and Th17-mediated neuro-inflammation, suggesting Rg3 as a potential candidate for resolving Th17-related autoimmune diseases. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2218-273X |
| DOI: | 10.3390/biom10010122 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce2e7fd470670c1ec59f9e1c552da38Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fce2e7fd470670c1ec59f9e1c552da38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2218273X |
|---|---|
| DOI: | 10.3390/biom10010122 |