Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats
| العنوان: | Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats |
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| المؤلفون: | Ling Zhang, Qing Xia, Xiaoda Yang, Xiaomin Zhao, Zhaofeng Sun, Yujing Tang, Hong-xin Cai, Xueqin Mao, Zuo-Li Xia |
| المصدر: | BioMetals. 21:563-570 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Vanadium, chemistry.chemical_element, General Biochemistry, Genetics and Molecular Biology, Diabetes Mellitus, Experimental, Biomaterials, chemistry.chemical_compound, Oral administration, Internal medicine, Diabetes mellitus, medicine, Animals, Insulin, Learning, Rats, Wistar, Sodium orthovanadate, Memory Disorders, Body Weight, Metals and Alloys, Lipid metabolism, Glucose Tolerance Test, Impaired memory, Streptozotocin, medicine.disease, Lipids, Cicer, Rats, Endocrinology, chemistry, Seedlings, Hyperglycemia, Toxicity, General Agricultural and Biological Sciences, medicine.drug |
| الوصف: | Vanadium compounds have been recognized for their hypoglycemic effects; however, potential short and long-term vanadium toxicity has slowed the acceptance for therapeutic use. In the present work, three batches of vanadium-enriched chickpea sprout (VCS) were prepared by incubating chickpea seeds in presence of 200, 100, and 50 microg/ml of sodium orthovanadate (SOV). The effects of oral administration of chickpea sprout (CS) and VCS food for 8 weeks on streptozotocin-induced (STZ) diabetic rats were investigated. Both CS and VCS food was found to ameliorate some hyperglycemic symptoms of the diabetic rats, i.e. improve lipid metabolism, decrease blood glucose level, prevent body weight loss, and reduce impairment of diabetic related spatial learning and memory. Serum insulin was substantially elevated in treated diabetic rats, which is probably one important reason for the hypoglycemic effect. Compared with CS alone, VCS100 food exhibited remarkably enhanced effectiveness in alleviating diabetes induced hyperglycemia and memory loss. Moreover, vanadium-enriched chickpeas appeared to abolish the vanadium induced toxicity associated with administration of this metal for diabetes during the 8-week study period. This study suggested further work of the vanadium speciation in CS and novel hypoglycemic mechanism for the antidiabetic activity of vanadium agents. Vanadium containing (VCS) food could be a dietary supplement for the diabetic status. |
| تدمد: | 1572-8773 0966-0844 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d908cc03641391802fb51dd5e5833796Test https://doi.org/10.1007/s10534-008-9142-yTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d908cc03641391802fb51dd5e5833796 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15728773 09660844 |
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