دورية أكاديمية
Blood M2-like monocyte polarization Is associated with calcific plaque phenotype in stable coronary artery disease: a sub-study of SMARToo1 clinical trial
| العنوان: | Blood M2-like monocyte polarization Is associated with calcific plaque phenotype in stable coronary artery disease: a sub-study of SMARToo1 clinical trial |
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| المؤلفون: | Sbrana, S., Cecchettini, A., Bastiani, L., Giorgi, N. di, Mazzone, A., Ceccherini, E., Vozzi, F., Caselli, C., Neglia, D., Clemente, A., Scholte, A.J.H.A., Parodi, O., Pelosi, G., Rocchiccioli, S. |
| المصدر: | Biomedicines |
| سنة النشر: | 2022 |
| المجموعة: | Leiden Repository (Leiden University) |
| مصطلحات موضوعية: | coronary artery disease, blood monocyte subsets, flow cytometry, plasma cytokines, coronary CT angiography, plaque calcium volume |
| الوصف: | Background: Atherosclerosis is a chronic inflammatory disease. The balance between proand anti-inflammatory factors, acting on the arterial wall, promotes less or more coronary plaque macro-calcification, respectively. We investigated the association between monocyte phenotypic polarization and CTCA-assessed plaque dense-calcium volume (DCV) in patients with stable coronary artery disease (CAD). Methods: In 55 patients, individual DCV component was assessed by quantitative CTCA and normalized to total plaque volume. Flow cytometry expression of CD14, CD16, CD18, CD11b, HLA-DR, CD163, CCR2, CCR5, CX3CR1 and CXCR4 was quantified. Adhesion molecules and cytokines were measured by ELISA. Results: DCV values were significantly associated, by multiple regression analysis, with the expression (RFI) of CCR5 (p = 0.04), CX3CR1 (p = 0.03), CCR2 (p = 0.02), CD163 (p = 0.005) on all monocytes, and with the phenotypic M2-like polarization ratio, RFI CCR5/CD11b (p = 0.01). A positive correlation with the increased expression of chemokines receptors CCR2, CCR5 and CX3CR1 on subsets Mont was also present. Among cytokines, the ratio between IL-10 and IL-6 was found to be strongly associated with DCV (p = 0.009). Conclusions: The association between DCV and M2-like phenotypic polarization of circulating monocytes indicates that plaque macro-calcification in stable CAD may be partly modulated by an anti-inflammatory monocyte functional state, as evidenced by cell membrane receptor patterns. ; Cardiology |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | lumc-id: 177710456; https://hdl.handle.net/1887/3567833Test |
| DOI: | 10.3390/biomedicines10030565 |
| الإتاحة: | https://doi.org/10.3390/biomedicines10030565Test https://hdl.handle.net/1887/3567833Test |
| رقم الانضمام: | edsbas.25929002 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/biomedicines10030565 |
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