Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography

التفاصيل البيبلوغرافية
العنوان: Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography
المؤلفون: Kuranov, Roman V., Qiu, Jinze, McElroy, Austin B., Estrada, Arnold, Salvaggio, Anthony, Kiel, Jeffrey, Dunn, Andrew K., Duong, Timothy Q., Milner, Thomas E.
المصدر: Biomedical Optics Express; March 2011, Vol. 2 Issue: 3 p491-504, 14p
مستخلص: Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO_2) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO_2 levels in a blood vessel phantom. DWP OCT SaO_2 is linearly correlated with blood-gas SaO_2 measurements. We demonstrate 6.3% precision in SaO_2 levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO_2 levels measured with DWP-OCT are identified and characterized.
قاعدة البيانات: Supplemental Index