دورية أكاديمية
SDF-1α predicts poor prognosis in patients with locally advanced esophageal squamous cell carcinoma receiving definitive concurrent chemoradiotherapy
| العنوان: | SDF-1α predicts poor prognosis in patients with locally advanced esophageal squamous cell carcinoma receiving definitive concurrent chemoradiotherapy |
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| المؤلفون: | Yen-Hao Chen, Hung-I Lu, Yu-Ming Wang, Chien-Ming Lo, Shang-Yu Chou, Shau-Hsuan Li |
| المصدر: | Biomedical Journal, Vol 45, Iss 3, Pp 522-532 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | SDF-1α, Esophageal cancer, Squamous cell carcinoma, Concurrent chemoradiotherapy, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Background: Stromal cell-derived factor-1α (SDF-1α) is a chemokine associated with tumor progression in various types of cancers. The current study aimed to evaluate whether pre-treatment or kinetics of SDF-1α can predict the prognosis in patients with esophageal squamous cell carcinoma (ESCC) receiving definitive concurrent chemoradiotherapy (CCRT). Methods: A total of 97 patients with ESCC were identified at Kaohsiung Chang Gung Memorial Hospital between January 2010 and December 2015. Serum concentration of SDF-1α was measured at day 0 (pre-treatment) and chemotherapy day 28 to determine its kinetics and the cut-off level of pre-chemotherapy SDF-1α was 1.5 ng/mL. Two ESCC cell lines, TE1 and KYSE30, were selected to evaluate the function of SDF-1α. Results: Univariate and multivariate analyses showed that pre-treatment SDF-1α ≥ 1.5 ng/mL and an increased SDF-1α level after treatment were significantly associated with worse progression-free survival (p = 0.021 and p = 0.008, respectively) and overall survival (p = 0.005 and p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2319-4170 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2319417021000615Test; https://doaj.org/toc/2319-4170Test |
| DOI: | 10.1016/j.bj.2021.05.004 |
| الوصول الحر: | https://doaj.org/article/34ca896895d74437a06990fedd4dd10cTest |
| رقم الانضمام: | edsdoj.34ca896895d74437a06990fedd4dd10c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23194170 |
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| DOI: | 10.1016/j.bj.2021.05.004 |