Coexpression of SFRP1 and WIF1 as a Prognostic Predictor of Favorable Outcomes in Patients with Colorectal Carcinoma
| العنوان: | Coexpression of SFRP1 and WIF1 as a Prognostic Predictor of Favorable Outcomes in Patients with Colorectal Carcinoma |
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| المؤلفون: | Shiyong Huang, Hongyu Wu, Shuming Zi, Shijie Yang, Long Cui, Peng Du, Zikang Li, XiaoMing Zhong, Chun Yang, Jun Gao, Rongfeng Song |
| المصدر: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| بيانات النشر: | Hindawi Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Article Subject, Carcinogenesis, Colorectal cancer, lcsh:Medicine, Repressor, WIF1, Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Secreted frizzled-related protein 1, medicine, Humans, Wnt Signaling Pathway, Adaptor Proteins, Signal Transducing, Aged, General Immunology and Microbiology, lcsh:R, Wnt signaling pathway, Membrane Proteins, General Medicine, DNA Methylation, Middle Aged, Prognosis, medicine.disease, Gene Expression Regulation, Neoplastic, Repressor Proteins, Treatment Outcome, DNA methylation, Cancer research, Intercellular Signaling Peptides and Proteins, Female, Signal transduction, Colorectal Neoplasms, Research Article, Signal Transduction |
| الوصف: | Colorectal tumorigenesis is ascribed to the activity of Wnt signaling pathway in a ligand-independent manner mainly through APC and CTNNB1 gene mutations and in a ligand-dependent manner through low expression of Wnt inhibitors such as WNT inhibitory factor 1 (WIF1) and secreted frizzled related protein 1 (SFRP1). In this study we found that WIF1 protein expression was increased and SFRP1 was decreased significantly in CRC tissue versus normal tissue, and high expression of WIF1 was associated with big tumor diameters and deep invasion, and loss of SFRP1 expression was associated with the left lesion site, deep invasion, and high TNM stage. Among the four expression patterns (WIF+/SFRP1+, WIF+/SFRP1−, WIF−/SFRP1+, and WIF−/SFRP1−) only coexpression of WIF1 and SFRP1 (WIF+/SFRP1+) was associated with favorable overall survival, together with low TNM stage, as an independent prognostic factor as shown in a multivariate survival model. The results indicated that WIF1 seemed to play an oncogenic role, while SFRP1 seemed to play an oncosuppressive role although both of them are secreted Wnt antagonists. Coexpression of SFRP1 and WIF1, rather than SFRP1 or WIF1 alone, could be used, together with low TNM stage, as a prognostic predictor of favorable outcomes in CRC. |
| وصف الملف: | text/xhtml |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf280931a728359aebcb925182c91120Test https://doi.org/10.1155/2014/256723Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf280931a728359aebcb925182c91120 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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