التفاصيل البيبلوغرافية
| العنوان: |
Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea. |
| المؤلفون: |
Béavogui, Abdoul Habib, Touré, Almamy Amara, Camara, Daouda, Doumbouya, Abdoulaye, Sylla, Malick Minkael, Touré, Sékou, Togo, Ahmadou Hamidou, Diallo, Mamadou Saliou, Delamou, Alexandre, Sagara, Issaka, Dicko, Alassane, Djimdé, Abdoulaye |
| المصدر: |
BioMed Research International; 8/3/2020, p1-10, 10p |
| مصطلحات موضوعية: |
MALARIA diagnosis, AGE distribution, ASPARTATE aminotransferase, BIOCHEMISTRY, BLOOD testing, CLINICAL trials, CREATININE, EOSINOPHILS, HEMOGLOBINS, LONGITUDINAL method, PHENOMENOLOGY, MONOCYTES, REFERENCE values, RURAL population, SEX distribution, SURVEYS, ALANINE aminotransferase, CROSS-sectional method, PLATELET count, MANN Whitney U Test |
| مصطلحات جغرافية: |
GUINEA |
| مستخلص: |
Guinea's reference ranges for biological parameters rely on those of Caucasian values. Variability in reference ranges according to the context is well-documented. We conducted this study for the purpose of future malaria clinical trials that assess the efficacy and safety of malaria drugs. A repeated cross-sectional study was carried out, in an apparently healthy cohort population. Surveys took place in Maferinyah rural community, which is located at 75 km from the capital. The 2.5th and 97.5th percentiles were determined nonparametrically and stood for reference intervals. Reference values were determined separately for males and females according to ranges of age (6-10 years of age; 11-15 years of age; 16-45 years of age). Differences between genders were tested using the Mann-Whitney test, while the Friedman test was performed to test differences within each gender group according to the seasons. A total of 450 volunteers were enrolled. The median age was 13. Males 16-45 years of age had significantly higher hematologic and biochemical values compared to a female of the same age (for hematological parameters: Mean Cell Hemoglobin Concentration MCHC p ≤ 0.001 , Platelets p ≤ 0.001 , monocytes p = 0.0305 , eosinophils p = 0.0225 ; for biochemical parameters: Aspartate aminotransferase AST p ≤ 0.001 , Alanine Aminotransferase ALT p ≤ 0.001 , creatinine p ≤ 0.001). We noticed significant seasonal variations for all the biochemical parameters and some hematologic parameters (Mean Corpuscular Hemoglobin MCH, MCHC, Mean Cell volume). This is the first study establishing hematologic and biochemical parameters in Guinea. These findings provide a useful guide for the clinical researchers and care providers. Studies on large scale and in different settings would be also desirable. [ABSTRACT FROM AUTHOR] |
|
Copyright of BioMed Research International is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder