Liver Autophagy in Anorexia Nervosa and Acute Liver Injury
| العنوان: | Liver Autophagy in Anorexia Nervosa and Acute Liver Injury |
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| المؤلفون: | Marouane Kheloufi, François Durand, Chantal M. Boulanger, Pierre-Emmanuel Rautou |
| المصدر: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| بيانات النشر: | Hindawi Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Programmed cell death, Anorexia Nervosa, acetaminophen overdose, Necrosis, lcsh:Medicine, Review Article, Biology, Models, Biological, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Autophagy, medicine, Animals, Humans, 030304 developmental biology, 2. Zero hunger, Liver injury, 0303 health sciences, General Immunology and Microbiology, medicine.diagnostic_test, Liver cell, lcsh:R, General Medicine, Liver Failure, Acute, medicine.disease, 3. Good health, Endocrinology, Liver, Liver biopsy, Hepatocytes, 030211 gastroenterology & hepatology, Chemical and Drug Induced Liver Injury, medicine.symptom, Homeostasis |
| الوصف: | Autophagy, a lysosomal catabolic pathway for long-lived proteins and damaged organelles, is crucial for cell homeostasis, and survival under stressful conditions. During starvation, autophagy is induced in numerous organisms ranging from yeast to mammals, and promotes survival by supplying nutrients and energy. In the early neonatal period, when transplacental nutrients supply is interrupted, starvation-induced autophagy is crucial for neonates’ survival. In adult animals, autophagy provides amino acids and participates in glucose metabolism following starvation. In patients with anorexia nervosa, autophagy appears initially protective, allowing cells to copes with nutrient deprivation. However, when starvation is critically prolonged and when body mass index reaches 13 kg/m2or lower, acute liver insufficiency occurs with features of autophagic cell death, which can be observed by electron microscopy analysis of liver biopsy samples. In acetaminophen overdose, a classic cause of severe liver injury, autophagy is induced as a protective mechanism. Pharmacological enhancement of autophagy protects against acetaminophen-induced necrosis. Autophagy is also activated as a rescue mechanism in response to Efavirenz-induced mitochondrial dysfunction. However, Efavirenz overdose blocks autophagy leading to liver cell death. In conclusion, in acute liver injury, autophagy appears as a protective mechanism that can be however blocked or overwhelmed. |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01117cb7f46b0a6319aac7c2700707b6Test https://doaj.org/article/47b3d2a514db494b9a47bf0a45dc7110Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....01117cb7f46b0a6319aac7c2700707b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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