Lactate Dehydrogenase in Hepatocellular Carcinoma: Something Old, Something New
| العنوان: | Lactate Dehydrogenase in Hepatocellular Carcinoma: Something Old, Something New |
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| المؤلفون: | Luca Faloppi, Kalliopi Andrikou, Michela Del Prete, Andrea Casadei Gardini, Maristella Bianconi, Mario Scartozzi, Riccardo Memeo, Alessandro Bittoni, Riccardo Giampieri, Stefano Cascinu |
| المساهمون: | Faloppi, Luca, Bianconi, Maristella, Memeo, Riccardo, Casadei Gardini, Andrea, Giampieri, Riccardo, Bittoni, Alessandro, Andrikou, Kalliopi, Del Prete, Michela, Cascinu, Stefano, Scartozzi, Mario |
| المصدر: | BioMed Research International, Vol 2016 (2016) BioMed Research International |
| بيانات النشر: | Hindawi Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Genetics and Molecular Biology (all), medicine.medical_specialty, Pathology, Immunology and Microbiology (all), medicine.medical_treatment, lcsh:Medicine, Review Article, Disease, Biology, Biochemistry, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Internal medicine, Lactate dehydrogenase, medicine, Humans, Glycolysis, Embolization, L-Lactate Dehydrogenase, General Immunology and Microbiology, Liver Neoplasms, lcsh:R, General Medicine, medicine.disease, Embolization, Therapeutic, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Potential biomarkers, Hepatocellular carcinoma, Anaerobic exercise, Biochemistry, Genetics and Molecular Biology (all) |
| الوصف: | Hepatocellular carcinoma (HCC) is the most common primary liver tumour (80–90%) and represents more than 5.7% of all cancers. Although in recent years the therapeutic options for these patients have increased, clinical results are yet unsatisfactory and the prognosis remains dismal. Clinical or molecular criteria allowing a more accurate selection of patients are in fact largely lacking. Lactic dehydrogenase (LDH) is a glycolytic key enzyme in the conversion of pyruvate to lactate under anaerobic conditions. In preclinical models, upregulation of LDH has been suggested to ensure both an efficient anaerobic/glycolytic metabolism and a reduced dependence on oxygen under hypoxic conditions in tumour cells. Data from several analyses on different tumour types seem to suggest that LDH levels may be a significant prognostic factor. The role of LDH in HCC has been investigated by different authors in heterogeneous populations of patients. It has been tested as a potential biomarker in retrospective, small, and nonfocused studies in patients undergoing surgery, transarterial chemoembolization (TACE), and systemic therapy. In the major part of these studies, high LDH serum levels seem to predict a poorer outcome. We have reviewed literature in this setting trying to resume basis for future studies validating the role of LDH in this disease. |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9eb0af43cb35b4328da03fdf0aaaf3fTest https://doaj.org/article/6c4060c0372f4caca864d49af2f0be56Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e9eb0af43cb35b4328da03fdf0aaaf3f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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