T Cell Exhaustion and CAR-T Immunotherapy in Hematological Malignancies
| العنوان: | T Cell Exhaustion and CAR-T Immunotherapy in Hematological Malignancies |
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| المؤلفون: | Heng Mei, Lu Tang, Yinqiang Zhang, Yu Hu |
| المصدر: | BioMed Research International, Vol 2021 (2021) BioMed Research International |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_treatment, T cell, Review Article, Immunotherapy, Adoptive, complex mixtures, General Biochemistry, Genetics and Molecular Biology, Immune system, Downregulation and upregulation, medicine, Tumor Microenvironment, Humans, Tumor microenvironment, Receptors, Chimeric Antigen, General Immunology and Microbiology, business.industry, Cancer, General Medicine, Immunotherapy, medicine.disease, Chimeric antigen receptor, Tumor antigen, medicine.anatomical_structure, Hematologic Neoplasms, Cancer research, Medicine, business, human activities |
| الوصف: | T cell exhaustion has been recognized to play an immunosuppressive role in malignant diseases. Persistent tumor antigen stimulation, the presence of inhibitory immune cells and cytokines in tumor microenvironment (TME), upregulated expression of inhibitory receptors, changes in T cell-related transcription factors, and metabolic factors can all result in T cell exhaustion. Strategies dedicated to preventing or reversing T cell exhaustion are required to reduce the morbidity from cancer and enhance the effectiveness of adoptive cellular immunotherapy. Here, we summarize the current findings of T cell exhaustion in hematological malignancies and chimeric antigen receptor T (CAR-T) immunotherapy, as well as the value of novel technologies, to inverse such dysfunction. Our emerging understanding of T cell exhaustion may be utilized to develop personalized strategies to restore antitumor immunity. |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024cf90b5195840b7693d1a67cf60ac2Test https://doaj.org/article/27da99b15b5e4ecc9f05478bbbd2d8b5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....024cf90b5195840b7693d1a67cf60ac2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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