Mitochondrial-Targeted Molecular Imaging in Cardiac Disease
| العنوان: | Mitochondrial-Targeted Molecular Imaging in Cardiac Disease |
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| المؤلفون: | You Zhou, Jing Lu, Jinhui Li |
| المصدر: | BioMed Research International BioMed Research International, Vol 2017 (2017) |
| بيانات النشر: | Hindawi, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Cardiac function curve, Pathology, medicine.medical_specialty, Heart Diseases, lcsh:Medicine, Review Article, 030204 cardiovascular system & hematology, Biology, Mitochondrion, General Biochemistry, Genetics and Molecular Biology, Mitochondria, Heart, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Heart metabolism, General Immunology and Microbiology, medicine.diagnostic_test, lcsh:R, General Medicine, Blood flow, Molecular Imaging, Positron emission tomography, Molecular imaging, Radiopharmaceuticals, Neuroscience, Perfusion, Emission computed tomography |
| الوصف: | The present study aimed to discuss the role of mitochondrion in cardiac function and disease. The mitochondrion plays a fundamental role in cellular processes ranging from metabolism to apoptosis. The mitochondrial-targeted molecular imaging could potentially illustrate changes in global and regional cardiac dysfunction. The collective changes that occur in mitochondrial-targeted molecular imaging probes have been widely explored and developed. As probes currently used in the preclinical setting still have a lot of shortcomings, the development of myocardial metabolic activity, viability, perfusion, and blood flow molecular imaging probes holds great potential for accurately evaluating the myocardial viability and functional reserve. The advantages of molecular imaging provide a perspective on investigating the mitochondrial function of the myocardium in vivo noninvasively and quantitatively. The molecular imaging tracers of single-photon emission computed tomography and positron emission tomography could give more detailed information on myocardial metabolism and restoration. In this study, series mitochondrial-targeted99mTc-,123I-, and18F-labeled tracers displayed broad applications because they could provide a direct link between mitochondrial dysfunction and cardiac disease. |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1ac7884aa7fe01ff8256a1a3dc796aTest http://europepmc.org/articles/PMC5468586Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ce1ac7884aa7fe01ff8256a1a3dc796a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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