مورد إلكتروني
B cell sub-types following acute malaria and associations with clinical immunity
| العنوان: | B cell sub-types following acute malaria and associations with clinical immunity |
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| بيانات النشر: | BioMed Central Ltd. 2016-03-03 |
| تفاصيل مُضافة: | Sullivan, Richard Ssewanyana, Isaac Wamala, Samuel Nankya, Felistas Jagannathan, Prasanna Tappero, Jordan Mayanja-Kizza, Harriet Muhindo, Mary Arinaitwe, Emmanuel Kamya, Moses Dorsey, Grant Feeney, Margaret Riley, Eleanor Drakeley, Chris Greenhouse, Bryan |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background Repeated exposure to Plasmodium falciparum is associated with perturbations in B cell sub-set homeostasis, including expansion atypical memory B cells. However, B cell perturbations immediately following acute malaria infection have been poorly characterized, especially with regard to their relationship with immunity to malaria. Methods To better understand the kinetics of B cell sub-sets following malaria, the proportions of six B cell sub-sets were assessed at five time points following acute malaria in four to 5 years old children living in a high transmission region of Uganda. B cell sub-set kinetics were compared with measures of clinical immunity to malaria—lower parasite density at the time of malaria diagnosis and recent asymptomatic parasitaemia. Results Atypical memory B cell and transitional B cell proportions increased following malaria. In contrast, plasmablast proportions were highest at the time of malaria diagnosis and rapidly declined following treatment. Increased proportions of atypical memory B cells were associated with greater immunity to malaria, whereas increased proportions of transitional B cells were associated with evidence of less immunity to malaria. Conclusions These findings highlight the dynamic changes in multiple B cell sub-sets following acute, uncomplicated malaria, and how these sub-sets are associated with developing immunity to malaria. |
| مصطلحات الفهرس: | Atypical memory B cells, Transitional B cells, Plasmablasts, Plasma cells Plasmodium falciparum, Malaria, Immunity, Research |
| URL: | |
| الإتاحة: | Open access content. Open access content Copyright 2016 Sullivan et al. |
| ملاحظة: | BioMed Central Ltd. English |
| أرقام أخرى: | UKBIO oai:biomedcentral.com:s12936-016-1190-0 950204645 |
| المصدر المساهم: | BIOMED CENT (BMC) From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn950204645 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |