Pirfenidone-loaded exosomes derived from pancreatic ductal adenocarcinoma cells alleviate fibrosis of premetastatic niches to inhibit liver metastasis
| العنوان: | Pirfenidone-loaded exosomes derived from pancreatic ductal adenocarcinoma cells alleviate fibrosis of premetastatic niches to inhibit liver metastasis |
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| المؤلفون: | Jing Zhao, Yun Zhu, Zhuojin Li, Jiawei Liang, Yin Zhang, Siqi Zhou, Yixuan Zhang, Zhiwen Fan, Yonghua Shen, Yifeng Liu, Feng Zhang, Shanshan Shen, Guifang Xu, Lei Wang, Ying Lv, Shu Zhang, Xiaoping Zou |
| المصدر: | Biomaterials Science. 10:6614-6626 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pancreatic Neoplasms, Liver Cirrhosis, Cell Line, Tumor, Liver Neoplasms, Biomedical Engineering, Humans, General Materials Science, Exosomes, Carcinoma, Pancreatic Ductal |
| الوصف: | Given the metastasis-promoting effect of pancreatic ductal adenocarcinoma (PDAC)-derived exosomes through activation of fibrotic premetastatic niches, targeting and intervening in premetastatic organs to inhibit distant metastasis have challenged researchers and clinicians. Herein, a self-biomimetic drug delivery system based on exosomes derived from PDAC (PF@PCCEs) was constructed to precisely deliver an antifibrotic drug (pirfenidone, PF) to fibrotic premetastatic organs. First, PDAC-derived exosomes were confirmed to remarkably promote liver fibrosis. Then the prepared PF@PCCEs were actively internalized by HSCs (hepatic stellate cells) and subsequently alleviated the activation of HSCs. Delivery of PF to the premetastatic liver affected the niche suitable for the colonization of circulating tumour cells, further suppressing liver metastasis of PDAC. Thus, the strategy for intervening in the formation of fibrotic premetastatic niches to inhibit liver metastasis of PDAC using PF@PCCEs might offer inspiration for the treatment of tumour metastasis. |
| تدمد: | 2047-4849 2047-4830 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35673ef91cb612a0e8724adfcb5f44c1Test https://doi.org/10.1039/d2bm00770cTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....35673ef91cb612a0e8724adfcb5f44c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20474849 20474830 |
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