The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest
| العنوان: | The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest |
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| المؤلفون: | Josef Dankiewicz, Jonas Jögi, Yvan Devaux, Patrik Gilje, Malin Rundgren, Pascal Stammet, Christian Hassager, John Bro-Jeppesen, Hans Friberg, Mariam Al-Mashat, David Erlinge, Martin Frydland, Jesper Kjaergaard |
| المصدر: | Gilje, P, Frydland, M, Bro-Jeppesen, J, Dankiewicz, J, Friberg, H, Rundgren, M, Devaux, Y, Stammet, P, Al-Mashat, M, Jögi, J, Kjærgaard, J, Hassager, C & Erlinge, D 2019, ' The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest ', Biomarkers, vol. 24, no. 1, pp. 29-35 . https://doi.org/10.1080/1354750X.2018.1499804Test |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Resuscitation, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Clinical Biochemistry, Pilot Projects, 030204 cardiovascular system & hematology, Targeted temperature management, Biochemistry, Out of hospital cardiac arrest, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, MiR-122, Humans, Lactic Acid, Survivors, Cardiopulmonary resuscitation, Mortality, Aged, Out-of-Hospital Cardiac Arrest/blood, business.industry, Cardiogenic shock, Case-control study, MicroRNAs/blood, Shock, Lactic Acid/blood, Middle Aged, medicine.disease, Cardiopulmonary Resuscitation, MicroRNAs, Case-Control Studies, 030220 oncology & carcinogenesis, Shock (circulatory), Cardiology, Female, medicine.symptom, Shock/blood, business, Out-of-Hospital Cardiac Arrest |
| الوصف: | Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. Methods: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. Results: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point. Conclusions: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission. |
| وصف الملف: | application/pdf |
| تدمد: | 1366-5804 1354-750X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80870bc1a7c54b5c354b7dbdcb3b3bf1Test https://doi.org/10.1080/1354750x.2018.1499804Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....80870bc1a7c54b5c354b7dbdcb3b3bf1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13665804 1354750X |
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