التفاصيل البيبلوغرافية
| العنوان: |
Circulating microRNAs as potential biomarkers for smoking-related interstitial fibrosis. |
| المؤلفون: |
Huang, Yuchuan, Dai, Ya, Zhang, Jie, Wang, Changguo, Li, Dongliang, Cheng, Jingqiu, Lu, Yanrong, Ma, Kuoyan, Tan, Lanlan, Xue, Fang, Qin, Bo |
| المصدر: |
Biomarkers; Aug2012, Vol. 17 Issue 5, p435-440, 6p, 1 Chart, 2 Graphs |
| مصطلحات موضوعية: |
MICRORNA, BIOMARKERS, FIBROSIS, INFLAMMATION, CYTOKINES, BLOOD plasma |
| مستخلص: |
Numerous efforts have been made to indentify reliable and predictive biomarkers to detect the early signs of smoking-induced lung disease. Using 6-month cigarette smoking in mice, we have established smoking-related interstitial fibrosis (SRIF). Microarray analyses and cytokine/chemokine biomarker measurements were made to select circulating microRNAs (miRNAs) biomarkers. We have demonstrated that specific miRNAs species (miR-125b-5p, miR-128, miR-30e, and miR-20b) were significantly changed, both in the lung tissue and in plasma, and exhibited mainstream (MS) exposure duration-dependent pathological changes in the lung. These findings suggested a potential use of specific circulating miRNAs as sensitive and informative biomarkers for smoking-induced lung disease. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
