التفاصيل البيبلوغرافية
| العنوان: |
Interleukin receptor family member ST2 concentrations in patients following heart transplantation. |
| المؤلفون: |
Januzzi, James L.1 (AUTHOR) jjanuzzi@partners.org, Horne, Benjamin D.2 (AUTHOR), Moore, Stephanie A.1 (AUTHOR), Galenko, Oxana3 (AUTHOR), Snow, Gregory L.2 (AUTHOR), Brunisholz, Kimberly D.2 (AUTHOR), Muhlestein, Joseph B.2 (AUTHOR), Alharethi, Rami2 (AUTHOR), Carlquist, John F.3 (AUTHOR), Budge, Deborah2 (AUTHOR), Rasmussen, Kismet2 (AUTHOR), Kfoury, Abdallah G.2 (AUTHOR) |
| المصدر: |
Biomarkers. May2013, Vol. 18 Issue 3, p250-256. 7p. |
| مصطلحات موضوعية: |
*HEART transplantation, *INTERLEUKIN receptors, *BIOMARKERS, *HOMOGRAFTS, *IMMUNOGLOBULINS |
| مستخلص: |
Objective: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT). Methods: sST2 concentrations were measured in 241 patients following OHT. Results: Elevated sST2 was associated with cellular rejection (CR) ≥1R, with highest rates of CR in the 4th sST2 quartile ( p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15-3.51; p = 0.01). Conclusion: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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