Anti-HIV-1 Activity of Poly(mandelic acid) Derivatives
| العنوان: | Anti-HIV-1 Activity of Poly(mandelic acid) Derivatives |
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| المؤلفون: | John A. Pojman, Victor Wyatt, Jelani Griffith, Andrew B. Lowe, David L. Wertz, Tara Craft, Yun-Yao Li, A. Robert Neurath, Marty Ward, Bing Yu, Nathan Strick |
| المصدر: | Biomacromolecules. 8:3308-3316 |
| بيانات النشر: | American Chemical Society (ACS), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Polymers and Plastics, Anti-HIV Agents, Bioengineering, HIV Envelope Protein gp120, Microanalysis, Biomaterials, chemistry.chemical_compound, Viral envelope, Materials Chemistry, Transition Temperature, Organic chemistry, Binding site, Spectroscopy, chemistry.chemical_classification, Molecular Structure, Spectrum Analysis, Water, Polymer, Mandelic acid, Fluorescence, Polyester, Solubility, chemistry, HIV-1, Mandelic Acids, Protein Binding, Nuclear chemistry |
| الوصف: | Homo- and heterochiral poly(mandelic acid)s (PMDAs) were synthesized under strongly acidic, mildly acidic, and nonacidic conditions. The water-soluble fractions of these polymers were evaluated with respect to their inhibitory activity against the human immunodeficiency virus (HIV-1). Polymers were prepared via a step-growth mechanism, yielding linear polyesters. The polymers were characterized by CHS elemental microanalysis, X-ray fluorescence (XRF), and FT-IR spectroscopy. Polymers prepared by the three methods have different structures. Both elemental microanalysis and XRF indicated the presence of S in those polymers prepared by treatment with concentrated H2SO4, which were the only ones exhibiting inhibitory and virucidal activity against HIV-1, mediated by their binding to cellular co-receptor binding sites on the virus envelope glycoprotein gp120. Additionally, FT-IR spectroscopy indicated the complete absence of C=O functionality in the H2SO4-prepared PMDA. |
| تدمد: | 1526-4602 1525-7797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275fa2f7c16e3e1579fa52da8248a9adTest https://doi.org/10.1021/bm070221yTest |
| رقم الانضمام: | edsair.doi.dedup.....275fa2f7c16e3e1579fa52da8248a9ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15264602 15257797 |
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