التفاصيل البيبلوغرافية
| العنوان: |
Impact on Outcomes of Human Leukocyte Antigen Matching by Allele-Level Typing in Adults with Acute Myeloid Leukemia Undergoing Umbilical Cord Blood Transplantation. |
| المؤلفون: |
Sanz, Jaime1 sanz_jai@gva.es, Jaramillo, Francisco J.1, Planelles, Dolores1, Montesinos, Pau1, Lorenzo, Ignacio1, Moscardó, Federico1, Martin, Guillermo1, López, Francisca1, Martínez, Jesús1, Jarque, Isidro1, de la Rubia, Javier1, Larrea, Luis1, Sanz, Miguel A.1, Sanz, Guillermo F.1 |
| المصدر: |
Biology of Blood & Marrow Transplantation. Jan2014, Vol. 20 Issue 1, p106-110. 5p. |
| مصطلحات موضوعية: |
*HLA histocompatibility antigens, *ALLELES, *ACUTE myeloid leukemia, *CORD blood transplantation, *DISEASE remission, *HEALTH outcome assessment |
| مستخلص: |
Abstract: This retrospective study analyzed the impact of directional donor-recipient human leukocyte antigen (HLA) disparity using allele-level typing at HLA-A, -B, -C, and -DRB1 in 79 adults with acute myeloid leukemia (AML) who received single-unit umbilical cord blood (UCB) transplant at a single institution. With extended high-resolution HLA typing, the donor-recipient compatibility ranged from 2/8 to 8/8. HLA disparity showed no negative impact on nonrelapse mortality (NRM), graft-versus-host (GVH) disease or engraftment. Considering disparities in the GVH direction, the 5-year cumulative incidence of relapse was 44% and 22% for patients receiving an UCB unit matched ≥ 6/8 and < 6/8, respectively (P = .04). In multivariable analysis, a higher HLA disparity in the GVH direction using extended high-resolution typing (Risk ratio [RR] 2.8; 95% confidence interval [CI], 1.5 to 5.1; P = .0009) and first complete remission at time of transplantation (RR 2.1; 95% CI, 1.2 to 3.8; P = .01) were the only variables significantly associated with an improved disease-free survival. In conclusion, we found that in adults with AML undergoing single-unit UCBT, an increased number of HLA disparities at allele-level typing improved disease-free survival by decreasing the relapse rate without a negative effect on NRM. [Copyright &y& Elsevier] |
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