Effects of Dietary Zinc Oxide Nanoparticles on Growth, Diarrhea, Mineral Deposition, Intestinal Morphology, and Barrier of Weaned Piglets
| العنوان: | Effects of Dietary Zinc Oxide Nanoparticles on Growth, Diarrhea, Mineral Deposition, Intestinal Morphology, and Barrier of Weaned Piglets |
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| المؤلفون: | Chao Wang, L. L. Zhang, Lili Zhang, Tian Wang, Xiang Zhong, Zhixiong Ying, Le Zhou, Jintian He |
| المصدر: | Biological Trace Element Research. 185:364-374 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Diarrhea, 0301 basic medicine, Swine, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Crypt, chemistry.chemical_element, Apoptosis, Weaning, Zinc, Occludin, Biochemistry, Transaminase, Inorganic Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Animal science, Lactate dehydrogenase, medicine, Animals, Intestinal Mucosa, Particle Size, Feces, Cell Proliferation, Minerals, Dose-Response Relationship, Drug, Biochemistry (medical), Diamine oxidase activity, General Medicine, Intestines, 030104 developmental biology, chemistry, Dietary Supplements, Nanoparticles, Zinc Oxide, medicine.symptom |
| الوصف: | This study was conducted to investigate effects of dietary zinc oxide nanoparticles (nano-ZnOs) on growth, diarrhea rate, mineral deposition (Zn, Fe, and Mn), intestinal morphology, and barrier of weaned piglets. A total of 384 weaned piglets (Duroc × Landrace × Yorkshire) in 4 groups were fed a basal diet supplemented with 0, 400, and 800 mg/kg nano-ZnOs or 3000 mg/kg ZnO for 14 days. Compared with the control group, 800 mg/kg nano-ZnOs and 3000 mg/kg ZnO significantly increased average daily gain and decreased diarrhea rate of weaned piglets. There was no significant difference among ZnO and nano-ZnO groups. ZnO and nano-ZnOs did not affect serum activities of glutamic oxalacetic transaminase, glutamic-pyruvic transaminase, and lactate dehydrogenase. However, ZnO and 800 mg/kg nano-ZnOs significantly increased zinc concentrations in plasma, liver, pancreas, and tibia, without affecting Fe and Mn concentrations. Compared with the control group, 800 mg/kg nano-ZnOs significantly reduced plasma diamine oxidase activity, decreased total aerobic bacterial population in mesenteric lymph node, enhanced mRNA expressions of occludin, ZO-1, IL-1β, IL-10, TNF-α, and ki67 in ileal mucosa, and increased villous height, width, crypt depth, and surface area. Compared to ZnO group, 800 mg/kg nano-ZnOs significantly decreased aerobic bacterial population, enhanced mRNA expressions of occludin, IL-1β, IL-10, and TNF-α, and reduced fecal zinc concentration. These results indicated that 800 mg/kg nano-ZnOs might be a potential substitute for 3000 mg/kg ZnO in diets of weaned piglets. |
| تدمد: | 1559-0720 0163-4984 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b611985a89a3ef1a9619b66ec2ad49Test https://doi.org/10.1007/s12011-018-1266-5Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....72b611985a89a3ef1a9619b66ec2ad49 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590720 01634984 |
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