Partial replication of a DRD4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test
| العنوان: | Partial replication of a DRD4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test |
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| المؤلفون: | Joseph A. Sergeant, Fernando Mulas, Michael Gill, Richard P. Ebstein, Eric Taylor, Philip Asherson, Keeley Joane Brookes, Ana Miranda, Aribert Rothenberger, Herbert Roeyers, Tobias Banaschewski, Hans-Christoph Steinhausen, Robert D. Oades, Kaixin Zhou, Jacques Eisenberg, Stephen V. Faraone, Jessica Lasky-Su, Barbara Franke, Jan K. Buitelaar, Margaret Thompson, Iris Manor, Edmund J.S. Sonuga-Barke |
| المصدر: | Biological Psychiatry, 62, 9, pp. 985-90 Biological Psychiatry, 62, 985-90 |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, Linkage disequilibrium, Genetics and epigenetic pathways of disease [NCMLS 6], Databases, Factual, Medizin, Neuroinformatics [DCN 3], Severity of Illness Index, 0302 clinical medicine, Perception and Action [DCN 1], Determinants in Health and Disease [EBP 1], Child, Promoter Regions, Genetic, Genetics, 0303 health sciences, Europe, Phenotype, Child, Preschool, Female, medicine.symptom, Psychology, Functional Neurogenomics [DCN 2], medicine.medical_specialty, Adolescent, Single-nucleotide polymorphism, Quantitative trait locus, Impulsivity, Mental health [NCEBP 9], Polymorphism, Single Nucleotide, Genomic disorders and inherited multi-system disorders [IGMD 3], 03 medical and health sciences, Quantitative Trait, Heritable, Cognitive neurosciences [UMCN 3.2], Genetic model, mental disorders, medicine, Attention deficit hyperactivity disorder, SNP, Humans, Genetic Predisposition to Disease, ddc:610, Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Psychiatry, Biological Psychiatry, 030304 developmental biology, Family Health, Receptors, Dopamine D4, Heritability, medicine.disease, Genetic defects of metabolism [UMCN 5.1], Attention Deficit Disorder with Hyperactivity, 030217 neurology & neurosurgery |
| الوصف: | Contains fulltext : 52515.pdf (Publisher’s version ) (Closed access) BACKGROUND: Previous research found an association between single nucleotide polymorphisms (SNPs) in the promoter region of DRD4 and statistically derived phenotypes generated from attention-deficit/hyperactivity disorder (ADHD) symptoms. We sought to replicate this finding by using the same methodology in an independent sample of ADHD individuals. METHODS: Four SNPs were genotyped in and around DRD4 in 2631 individuals in 642 families. We developed a quantitative phenotype at each SNP by weighting nine inattentive and nine hyperactive-impulsive symptoms. The weights were selected to maximize the heritability at each SNP. Once a quantitative phenotype was generated at each SNP, the screening procedure implemented in PBAT was used to select and test the five SNPs/genetic model combinations with the greatest power to detect an association for DRD4. RESULTS: One of the four SNPs was associated with the quantitative phenotypes generated from the ADHD symptoms (corrected p-values = .02). A rank ordering of the correlation between each of the ADHD symptoms and the quantitative phenotype suggested that hyperactive-impulsive symptoms were more strongly correlated with the phenotype; however, including inattentive symptoms was necessary to achieve a significant result. CONCLUSIONS: This study partially replicated a previous finding by identifying an association between rs7124601 and a quantitative trait generated from ADHD symptoms. The rs7124601 is in linkage disequilibrium (LD) with the SNPs identified previously. In contrast to the previous study, this finding suggests that both hyperactive-impulsive and inattentive symptoms are important in the association. |
| وصف الملف: | application/pdf |
| تدمد: | 0006-3223 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60acaf5351ac5aab860e846034a33b68Test https://pubmed.ncbi.nlm.nih.gov/17560555Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....60acaf5351ac5aab860e846034a33b68 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00063223 |
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