Amygdala volume marks the acute state in the early course of depression
| العنوان: | Amygdala volume marks the acute state in the early course of depression |
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| المؤلفون: | Guido van Wingen, Mark Rijpkema, Robbert-Jan Verkes, Guillén Fernández, Bozena Goraj, Richard C. Oude Voshaar, Indira Tendolkar, Koen van Oijen, Jan K. Buitelaar, Philip van Eijndhoven |
| المساهمون: | Other departments |
| المصدر: | Biological Psychiatry, 65, 812-8 Biological Psychiatry, 65, 9, pp. 812-8 Biological psychiatry, 65(9), 812-818. Elsevier USA |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, 110 012 Social cognition of verbal communication, Adolescent, Hippocampus, Aetiology, screening and detection [ONCOL 5], Mental health [NCEBP 9], Severity of Illness Index, Amygdala, Neuroimaging, 130 000 Cognitive Neurology & Memory, Internal medicine, Perception and Action [DCN 1], medicine, Humans, Biological Psychiatry, Depression (differential diagnoses), First episode, Depressive Disorder, Major, Neuropsychology, Brain, Organ Size, Middle Aged, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, nervous system, 130 027 Brain Imaging Genetics - Alzheimer Disease, Case-Control Studies, Brain size, Cardiology, Major depressive disorder, Female, Psychology, Neuroscience |
| الوصف: | Contains fulltext : 77468.pdf (Publisher’s version ) (Closed access) BACKGROUND: The amygdala and hippocampus play a key role in the neural circuitry mediating depression. It remains unclear how much structural and functional changes of amygdala and hippocampus reflect the acute state of depression or an underlying neurobiological trait marker of depression. METHODS: High-resolution anatomical images were acquired in 20 medication-naive major depressive disorder (MDD) patients with a current first episode, 20 medication-free patients recovered from a first episode of MDD, and 20 healthy control subjects that were matched for age, gender, and level of education. Manual volumetry of amygdala and hippocampus was performed on coronal images. Volumetric measurements of brain volume and intracranial volume were acquired with automatic segmentation procedures. RESULTS: Both amygdalae were significantly enlarged in currently depressed patients, whereas there was no significant difference between recovered patients and control subjects. The amygdala enlargement correlated positively with the severity of depressive state but with no other clinical or neuropsychological variable. The hippocampal volume did not differ between groups. CONCLUSIONS: A state related increase of amygdala volume can be detected early in the course of MDD. Neurotoxic effects might account for the fact that state-related amygdala enlargement has not been found in recurrent depression with relative long illness duration. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0006-3223 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3db7317d9138cbba00b3ab41e91b54eTest https://doi.org/10.1016/j.biopsych.2008.10.027Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....c3db7317d9138cbba00b3ab41e91b54e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00063223 |
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