التفاصيل البيبلوغرافية
| العنوان: |
Human carbonic anhydrase VII protects cells from oxidative damage. |
| المؤلفون: |
Del Giudice, Rita, Monti, Daria M., Truppo, Emanuela, Arciello, Angela, Supuran, Claudiu T., De Simone, Giuseppina, Monti, Simona M. |
| المصدر: |
Biological Chemistry; Oct2013, Vol. 394 Issue 10, p1343-1348, 6p |
| مصطلحات موضوعية: |
OXIDATIVE stress, CARBONIC anhydrase, HYDRATION, CYTOSOL, REACTIVE oxygen species, APOPTOSIS, EUKARYOTIC cells |
| مستخلص: |
Human carbonic anhydrase (hCA) VII is a cytosolic enzyme with high carbon dioxide hydration activity. Recently, S-glutathionylation of two cysteine residues from the enzyme was revealed, suggesting a new role as oxygen radical scavenger. We analyzed the effect of native and tetramutated hCA VII (all cysteines mutated into serines) in a eukaryotic system by stressing cells with an oxidant agent. Results clearly show that native hCA VII can protect cells from oxidative damage by preventing the apoptosis cascade and that cysteines play a leading role in this process. Our findings definitively confirm hCA VII protective role toward oxidative insult. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
