Differential Expression of System L Amino Acid Transporters during Wound Healing Process in the Skin of Young and Old Rats
| العنوان: | Differential Expression of System L Amino Acid Transporters during Wound Healing Process in the Skin of Young and Old Rats |
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| المؤلفون: | Heung-Joong Kim, Kyung Jin Park, Chun Sung Kim, Joo-Cheol Park, Yoshikatsu Kanai, Moon-Jin Jeong, Do-Seon Lim, Yeong Mu Ko, Soon-Jeong Jeong, Do Kyung Kim, Hitoshi Endou |
| المصدر: | Biological and Pharmaceutical Bulletin. 31:395-399 |
| بيانات النشر: | Pharmaceutical Society of Japan, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, Amino Acid Transport System y+, Pharmaceutical Science, Large Neutral Amino Acid-Transporter 1, Rats, Sprague-Dawley, Internal medicine, medicine, Animals, Differential expression, Skin, Pharmacology, Skin repair, chemistry.chemical_classification, Wound Healing, integumentary system, System L, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Fusion Regulatory Protein 1, Light Chains, Regeneration (biology), Transporter, General Medicine, Rats, Surgery, Amino acid, Panniculus carnosus, Disease Models, Animal, Protein Subunits, Endocrinology, chemistry, business, Wound healing |
| الوصف: | In order to elucidate the role of the system L-type amino acid transporters (LATs) in the wound healing process of aged and young subjects, we investigated the expression of LAT1, LAT2 and their subunit 4F2hc in the skin healing process after artificial wounds of dorsal skin in the young and old rats. Methods: The 1 cm full-thickness incisional wounds were made through the skin and panniculus carnosus muscle. The wounds were harvested at days 1, 3, 5 and 7 post-wounding, the experimental controls were harvested the skin of rat without wounds and the various analyses were performed. Results: In young rats, gradually and noticeable wound healing was detected, however, in old rats, wound healing was found to be greatly delayed. In young rats, the expression of LAT1 was increased rapidly on the day 1 after wound induction, on the other hand, in old rats, the expression of LAT1 after wound induction was not different from the control group. In young rats, the expression of LAT2 after the induction of wound was not different from the control group, however in old rats, the expression of LAT2 on the day 1 of wound induction was rapidly elevated. Conclusion: These results suggest that the LAT1 and LAT2 increase in the wound healing process after cell injury in young and old rats, respectively. |
| تدمد: | 1347-5215 0918-6158 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062096f6252d81c3e4e05839f41dbd6aTest https://doi.org/10.1248/bpb.31.395Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....062096f6252d81c3e4e05839f41dbd6a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13475215 09186158 |
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