Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship
| العنوان: | Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship |
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| المؤلفون: | Masao Hattori, Yukihisa Mukarami, Norio Nakamura, Atef A. Abdel-Hafez, Tarek Mohamed, Nadia M. Mahfouz, Meselhy R. Meselhy, Mahmoud A. El-Gendy, Hiroshi Watanabe |
| المصدر: | Biological and Pharmaceutical Bulletin. 21:1174-1179 |
| بيانات النشر: | Pharmaceutical Society of Japan, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Bridged-Ring Compounds, Male, medicine.medical_specialty, Paeonia lactiflora, Scopolamine, Pharmaceutical Science, Amnesia, Pharmacology, Pharmacognosy, Benzoates, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Glucosides, Avoidance Learning, medicine, Animals, Memory disorder, Latency (engineering), Mice, Inbred ICR, biology, General Medicine, Paeoniflorin, medicine.disease, biology.organism_classification, Skeleton (computer programming), Surgery, chemistry, Tacrine, Monoterpenes, medicine.symptom, Drugs, Chinese Herbal, medicine.drug |
| الوصف: | Paeoniflorin (1) and its derivatives having in common a cage-like pinane skeleton with hemiketal-acetal system, were evaluated for their effects on memory impairment induced by scopolamine in mice using a step-down type passive avoidance task. In the test session, 1 and its derivatives were intraperitoneally (i.p.) administered at doses of 0.002, 0.01, 0.02 and 0.2 mmol/kg, and 30 min later (15 min before the experiment), scopolamine (1 mg/kg, i.p.) was given. These compounds showed dose-dependent attenuation in a dose range of 0.002-0.02 mmol/kg and also enhancement of scopolamine-induced decrease in step-down latency. The effects of these compounds, except that of 2',3',4',5'-O-tetraacetyl-3-O-methylpaeoniflorin (8), followed a bell-shaped dose response profile. 8-Debenzoyl-6-deglucosyl-3-O-methylpaeoniflorin (6) showed no significant increase in the step-down latency at all tested doses. Maximum step-down latency was obtained by 3-O-methylpaeoniflorin (3) and 2',3,3',4',5'-penta-O-methylpaeoniflorin (7) (the minimal effective dose was 0.002 mmol/kg). Relative to 3, debenzoylation, as in 8-debenzoyl-3-O-methylpaeoniflorin (4), slightly increased the latency, while deglucosylation, as in 6-deglucosyl-3-O-methylpaeoniflorin (5), significantly reduced the prolongation of latency. Removal of both glucose and benzoyl moieties resulted in the loss of activity as seen in 6. These results revealed that, in addition to the cage-like pinane skeleton, the benzoyl and the glucosyl moieties are important structural elements of the paeoniflorin skeleton as its effects on scopolamine-induced amnesia. |
| تدمد: | 1347-5215 0918-6158 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b476fcd159d8e9ceff07f2f8d7a17396Test https://doi.org/10.1248/bpb.21.1174Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b476fcd159d8e9ceff07f2f8d7a17396 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13475215 09186158 |
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