Enterotype Variations of the Healthy Human Gut Microbiome in Different Geographical Regions
| العنوان: | Enterotype Variations of the Healthy Human Gut Microbiome in Different Geographical Regions |
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| المؤلفون: | Vikas Sharma, Fauzul Mobeen, Prakash Tulika |
| المصدر: | Bioinformation |
| بيانات النشر: | Biomedical Informatics, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, healthy human gut microbiome, inter-continental, biology, Firmicutes, Clostridiales, geographical factor, food and beverages, Bacteroidetes, Zoology, General Medicine, Hypothesis, biology.organism_classification, 03 medical and health sciences, 030104 developmental biology, Prevotella, Enterotype, Microbiome, Bacteroides, Ruminococcaceae |
| الوصف: | Enterotypes are used for classifying individuals based on the gut microbiome. A number of studies are available to find the Enterotypes in healthy individuals; however, most of them lack comparisons at the world level. We analyzed the healthy human gut microbiomes of 495 datasets available in the European Nucleotide Archive (ENA) database derived from fifteen countries from four continents. Firmicutes and Bacteroidetes were the two most abundant phyla in the healthy human gut, worldwide. A high ratio of Proteobacteriato Actinobacteria and a low abundance of Prevotella were identified as the indicators of IBD. Prevotella, Bacteroides, and Bifidobacterium were identified as the Enterotypes in the inter-continental comparisons. At the intra-continental level, two (Bacteroides and Ruminococcaceae), four (Faecalibacterium, Bacteroides, Prevotella, and Clostridiales), and two (Prevotella, Bacteroides/Bifidobacterium) Enterotypes were identified in the American, European, and Asian continents, respectively. In addition, a high abundance of the unknown genus of Ruminococcaeae was observed in the Colombian human gut microbiome. A substantial impact of the geographical distance was observed on human gut microbiome variations, demonstrating a cumulative effect of factors, including dietary habits, genetics, lifestyle, environment, and climate, etc. |
| تدمد: | 0973-2063 0973-8894 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa462ced6681fe7d6d2486f4e42909fTest https://doi.org/10.6026/97320630014560Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....afa462ced6681fe7d6d2486f4e42909f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09732063 09738894 |
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