CaSiAn: a Calcium Signaling Analyzer tool
| العنوان: | CaSiAn: a Calcium Signaling Analyzer tool |
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| المؤلفون: | Aymeric Fouquier d'Hérouël, Kamil Grzyb, Francesca Peri, Mahsa Moein, Alexander Skupin, Alexander D. Crawford, Shinya Komoto, Teresa G. Martins |
| المصدر: | Bioinformatics |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Statistics and Probability, Spectrum analyzer, Cell type, Computer science, computer.software_genre, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Humans, Calcium Signaling, Molecular Biology, Calcium signaling, Programming language, Systems Biology, SIGNAL (programming language), Process (computing), Applications Notes, Computer Science Applications, Computational Mathematics, 030104 developmental biology, Computational Theory and Mathematics, Spike (software development), computer, Software, 030217 neurology & neurosurgery |
| الوصف: | Summary Ca2+ is a central second messenger in eukaryotic cells that regulates many cellular processes. Recently, we have indicated that typical Ca2+ signals are not purely oscillatory as widely assumed, but exhibit stochastic spiking with cell type and pathway specific characteristics. Here, we present the Calcium Signaling Analyzer (CaSiAn), an open source software tool that allows for quantifying these signal characteristics including individual spike properties and time course statistics in a semi-automated manner. CaSiAn provides an intuitive graphical user interface allowing experimentalists to easily process a large amount of Ca2+ signals, interactively tune peak detection, revise statistical measures and access the quantified signal properties as excel or text files. Availability and implementation CaSiAn is implemented in Java and available on Github (https://github.com/mmahsa/CaSiAnTest) as well as on the project page (http://r3lab.uni.lu/web/casaTest). Supplementary information Supplementary data are available at Bioinformatics online. |
| تدمد: | 1460-2059 1367-4803 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd9d486f9bee09bb01161524ad350b4Test https://doi.org/10.1093/bioinformatics/bty281Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fdd9d486f9bee09bb01161524ad350b4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602059 13674803 |
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