المؤلفون: Ian R. Kill, Wendy Ofosu, Joanna M. Bridger, Craig S. Clements, Evgeny M. Makarov, David Tree, Christopher H. Eskiw, Mehmet U. Bikkul

المصدر: Biogerontology

مصطلحات موضوعية: 0301 basic medicine, Aging, N-acetyl cysteine, Farnesyltransferase, Hutchinson-Gilford Progeria Syndrome, Progerin, LMNA, zoledronic acid, 0302 clinical medicine, Progeria, Enzyme Inhibitors, Pravastatin, farnesyl transferase inhibitors, pravastatin, biology, integumentary system, Chemistry, Lamin Type A, embryonic structures, Mevalonate pathway, medicine.drug, Research Article, congenital, hereditary, and neonatal diseases and abnormalities, Mevalonic Acid, Cell Line, 03 medical and health sciences, Internal lamin foci, medicine, Humans, Rapamycin, PI3K/AKT/mTOR pathway, Zoledronic acid, nuclear lamins, Hutchinson–Gilford progeria syndrome, rapamycin, Farnesyl transferase inhibitors, nutritional and metabolic diseases, medicine.disease, 030104 developmental biology, progerin, biology.protein, Cancer research, Nuclear lamins, Geriatrics and Gerontology, Gerontology, 030217 neurology & neurosurgery, Lamin

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6b2fd09330521c2ec71ca71051a6afTest
http://europepmc.org/articles/PMC6535420Test

المؤلفون: Mehmet U. Bikkul, Joanna M. Bridger, Craig S. Clements, Lauren S. Godwin, Ian R. Kill, Martin W. Goldberg

المصدر: Biogerontology
Biogerontology, 2018, Vol.19(6), pp.579-602 [Peer Reviewed Journal]

مصطلحات موضوعية: 0301 basic medicine, Aging, congenital, hereditary, and neonatal diseases and abnormalities, Biology, medicine.disease_cause, Progeroid syndromes, Cell Line, LMNA, 03 medical and health sciences, Progeria, Prenylation, Genome organisation, Farnesyltransferase inhibitors, medicine, Farnesyltranstransferase, Humans, Rapamycin, Insulin-Like Growth Factor I, Sirolimus, Mutation, Hutchinson–Gilford progeria syndrome, integumentary system, Diphosphonates, Genome, Human, Farnesyltransferase inhibitor, nutritional and metabolic diseases, Membrane Proteins, Metalloendopeptidases, Fibroblasts, medicine.disease, Progerin, Lamin Type A, Lamins, 030104 developmental biology, COMET assay, Cancer research, DNA damage, Drug Therapy, Combination, Female, Geriatrics and Gerontology, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Gerontology, Protein Processing, Post-Translational, Lamin, Research Article

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429d5898315377b4d14f0feadec93d82Test
https://pubmed.ncbi.nlm.nih.gov/29907918Test