التفاصيل البيبلوغرافية
| العنوان: |
An update of Coenzyme Q_{10} implications in male infertility: Biochemical and therapeutic aspects. |
| المؤلفون: |
Mancini, A., De Marinis, L., Littarru, G. P., Balercia, G. |
| المصدر: |
Biofactors; 2005, Vol. 25 Issue 1-4, p165-174, 10p, 3 Charts |
| مصطلحات موضوعية: |
COENZYMES, MALE infertility, SPERMATOZOA, HUMAN fertility, GENITAL diseases, UBIQUINONES, REACTIVE oxygen species, PHOTOSYNTHETIC oxygen evolution |
| مستخلص: |
This review is focused upon the role of coenzyme Q_{10} in male infertility in the light of a broader issue of oxidative damage and antioxidant defence in sperm cells and seminal plasma. Reactive oxygen species play a key pathogenetic role in male infertility besides having a well-recognized physiological function. The deep involvement of coenzyme _{10} in mitochondrial bioenergetics and its antioxidant properties are at the basis of its role in seminal fluid. Following the early studies addressing its presence in sperm cells and seminal plasma, the relative distribution of the quinone between these two compartments was studied in infertile men, with special attention to varicocele. The reduction state of CoQ_{10} in seminal fluid was also investigated. After the first in vitro experiments CoQ_{10} was administered to a group of idiopathic asthenozoospermic infertile patients. Seminal analysis showed a significant increase of CoQ_{10} both in seminal plasma and in sperm cells, together with an improvement in sperm motility. The increased concentration of CoQ_{10} in seminal plasma and sperm cells, the improvement of semen kinetic features after treatment, and the evidence of a direct correlation between CoQ_{10} concentrations and sperm motility strongly support a cause/effect relationship. From a general point of view, a deeper knowledge of these molecular mechanisms could lead to a new insight into the so-called unexplained infertility. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
