The role of oxidants and vitamin C on neutrophil apoptosis and clearance
| العنوان: | The role of oxidants and vitamin C on neutrophil apoptosis and clearance |
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| المؤلفون: | Mark B. Hampton, Margreet C.M. Vissers |
| المصدر: | Biochemical Society Transactions. 32:499-501 |
| بيانات النشر: | Portland Press Ltd., 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Vitamin, Staphylococcus aureus, Necrosis, Neutrophils, Apoptosis, Ascorbic Acid, Phosphatidylserines, Biology, Biochemistry, Monocytes, Mice, chemistry.chemical_compound, Chronic granulomatous disease, medicine, Animals, Granuloma, Vitamin C, Macrophages, Hydrogen Peroxide, Phosphatidylserine, Oxidants, medicine.disease, chemistry, Immunology, medicine.symptom, Intracellular |
| الوصف: | We have investigated the role of neutrophil oxidants in the surface changes that result in recognition and uptake of neutrophils by macrophages. We have shown that H2O2 produced by stimulated neutrophils is essential for the surface expression of phosphatidylserine. This does not occur in neutrophils from mice with chronic granulomatous disease and may explain the formation of granuloma in this condition. We have also investigated the role of intracellular vitamin C on neutrophil apoptosis. Cells from vitamin C-deficient mice were found to be less likely to undergo both spontaneous and oxidant-induced apoptosis, with eventual necrosis being the most probable outcome. |
| تدمد: | 1470-8752 0300-5127 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11bd957c45068579ddf5f8d3ddc2374Test https://doi.org/10.1042/bst0320499Test |
| رقم الانضمام: | edsair.doi.dedup.....b11bd957c45068579ddf5f8d3ddc2374 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708752 03005127 |
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