Regulation of the ALK1 ligands, BMP9 and BMP10
| العنوان: | Regulation of the ALK1 ligands, BMP9 and BMP10 |
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| المؤلفون: | Wei Li, Richard M. Salmon, Nicholas W. Morrell, He Jiang |
| المساهمون: | Li, Wei [0000-0002-1924-3120], Morrell, Nicholas [0000-0001-5700-9792], Apollo - University of Cambridge Repository |
| المصدر: | Biochemical Society Transactions. 44:1135-1141 |
| بيانات النشر: | Portland Press Ltd., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Angiogenesis, Activin Receptors, Type II, Biology, bone morphogenetic protein 9 (BMP9), Ligands, Bone morphogenetic protein, Models, Biological, Biochemistry, 03 medical and health sciences, activin receptor-like kinase 1 (ALK1), Neoplasms, Internal medicine, Growth Differentiation Factor 2, medicine, Dalantercept, Animals, Humans, Receptor, BMP receptor type II (BMPR-II), Kinase, bone morphogenetic protein 10 (BMP10), Bone morphogenetic protein 10, BMPR2, Growth Differentiation Factors, 030104 developmental biology, Endocrinology, Bone Morphogenetic Proteins, endothelial cell, Cancer research, Endothelium, Vascular, Signal transduction, signal transduction |
| الوصف: | Bone morphogenetic protein (BMP)9 and BMP10 are high affinity ligands for activin receptor-like kinase 1 (ALK1), a type I BMP receptor mainly expressed on vascular endothelial cells (ECs). ALK1-mediated BMP9/BMP10 signalling pathways have emerged as essential in EC biology and in angiogenesis. Several genetic mutations in the genes encoding the ligands and receptors of this pathway have been reported in two cardiovascular diseases, pulmonary arterial hypertension (PAH) and hereditary haemorrhagic telangiectasia (HHT). Administration of recombinant BMP9 reverses experimental PAH in preclinical rodent models. Dalantercept, an Fc-fusion protein of the extracellular domain of ALK1 and a ligand trap for BMP9 and BMP10, is in phase II clinical trials for anti-tumour angiogenesis. Understanding the regulation of BMP9 and BMP10, at both gene and protein levels, under physiological and pathological conditions, will reveal essential information and potential novel prognostic markers for the BMP9/BMP10-targeted therapies. |
| وصف الملف: | application/pdf |
| تدمد: | 1470-8752 0300-5127 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff43c0660e851ee31237d0e521507e1eTest https://doi.org/10.1042/bst20160083Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ff43c0660e851ee31237d0e521507e1e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708752 03005127 |
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