Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family
| العنوان: | Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family |
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| المؤلفون: | Wen-Chih Lee, Show Wan Lou, Ming Wei Kuo, Bon Chu Chung, Woon-Khiong Chan, John H. Postlethwait |
| المصدر: | Biochemical Journal. 389:19-26 |
| بيانات النشر: | Portland Press Ltd., 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Nuclear gene, Molecular Sequence Data, Receptors, Cytoplasmic and Nuclear, Biology, Steroidogenic Factor 1, Synteny, Biochemistry, Evolution, Molecular, Gene mapping, Gene Duplication, Gene duplication, Gene cluster, Animals, Humans, Gene family, RNA, Messenger, Cloning, Molecular, Molecular Biology, Gene, Zebrafish, Phylogeny, Homeodomain Proteins, Genetics, Models, Genetic, Receptors, Notch, Chromosome Mapping, Gene Expression Regulation, Developmental, Cell Biology, Zebrafish Proteins, biology.organism_classification, DNA-Binding Proteins, Multigene Family, Tandem exon duplication, Research Article, Transcription Factors |
| الوصف: | Fushi tarazu factor 1 (Ftz-F1, NR5A) is a zinc-finger transcription factor that belongs to the nuclear receptor superfamily and regulates genes that are involved in sterol and steroid metabolism in gonads, adrenals, liver and other tissues. To understand the evolutionary origins and developmental genetic relationships of the Ftz-F1 genes, we have cloned four homologous Ftz-f1 genes in zebrafish, called ff1a, ff1b, ff1c and ff1d. These four genes have different temporal and spatial expression patterns during development, indicating that they have distinct mechanisms of genetic regulation. Among them, the ff1a expression pattern is similar to mammalian Nr5a2, while the ff1b pattern is similar to that of mammalian Nr5a1. Genetic mapping experiments show that these four ff1 genes are located on chromosome segments conserved between the zebrafish and human genomes, indicating a common ancestral origin. Phylogenetic and conserved synteny analysis show that ff1a is the orthologue of NR5A2, and that ff1b and ff1d genes are co-orthologues of NR5A1 that arose by a gene-duplication event, probably a whole-genome duplication, in the ray-fin lineage, and each gene is located next to an NR6A1 co-orthologue as in humans, showing that the tandem duplication occurred before the divergence of human and zebrafish lineages. ff1c does not have a mammalian counterpart. Thus we have characterized the phylogenetic relationships, expression patterns and chromosomal locations of these Ftz-F1 genes, and have demonstrated their identities as NR5A genes in relation to the orthologous genes in other species. |
| تدمد: | 1470-8728 0264-6021 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4389ebeeb0b47820e010edc6c15f9bacTest https://doi.org/10.1042/bj20050005Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4389ebeeb0b47820e010edc6c15f9bac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708728 02646021 |
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