Platelet Rho GTPases–a focus on novel players, roles and relationships
| العنوان: | Platelet Rho GTPases–a focus on novel players, roles and relationships |
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| المؤلفون: | Goggs, Robert, Williams, Christopher M., Mellor, Harry, Poole, Alastair W. |
| المصدر: | Biochemical Journal |
| بيانات النشر: | Portland Press Ltd., 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | rho GTP-Binding Proteins, Syk, spleen tyrosine kinase, Platelet Aggregation, TRIO, triple functional domain containing protein, Review Article, Cdc42, cell division control protein 42, Rac, Ras-related C3 botulinum toxin substrate, ROCK, Rho kinase, MLC, myosin light chain, shape change, Ena, enabled, MTSS1, metastasis suppressor protein 1, FcR, Fc receptor, AP-MS, affinity-purification mass spectrometry, ARP2/3, actin related protein 2/3 complex, Rif, Rho in filopodia (RhoF), WASP, Wiskott–Aldrich syndrome protein, ECM, extracellular matrix, LARG, leukaemia-associated Rho GEF (ARHGEF12), secretion, PI3K, phosphoinositide 3-kinase, PREX-1, PI(3,4,5)P3-dependent Rac exchanger 1 protein, Signal Transduction, VWF, von Willebrand factor, Blood Platelets, PAR, protease activated receptor, NSF, N-ethylmaleimide-sensitive factor, CRP, collagen-related peptide, SNARE, soluble N-ethylmaleimide attachment protein receptors, PF4, platelet factor-4, GEF, guanine nucleotide exchange factor, PLC, phospholipase C, PAK, P21-activated kinase, LAT, linker for activation of T-cells, PKC, protein kinase C, Animals, Humans, cell division control protein 42 (Cdc42), thrombosis, Rho GTPase, Ras homology family GTPase, Rif, ITAM, immunoreceptor tyrosine-based activation motif, Platelet Activation, GDI, guanine nucleotide dissociation inhibitor, RhoG, IMD, IRSp53 and MIM homology domain, ELMO, engulfment and cell motility, VAMP, vesicle-associated membrane protein, F-actin, filamentous actin, TCR, T-cell receptor, GAP, GTPase activating protein, ARHGEF, Rho guanine nucleotide exchange factor, GP, glycoprotein, VASP, vasodilator-stimulated phosphoprotein, DOCK, dedicator of cytokinesis |
| الوصف: | Rho GTPases are critical for platelet function. Although the roles of RhoA, Rac and Cdc42 are characterized, platelets express other Rho GTPases, whose activities are less well understood. This review summarizes our understanding of the roles of platelet Rho GTPases and focuses particularly on the functions of Rif and RhoG. In human platelets, Rif interacts with cytoskeleton regulators including formins mDia1 and mDia3, whereas RhoG binds SNARE-complex proteins and cytoskeletal regulators ELMO and DOCK1. Knockout mouse studies suggest that Rif plays no critical functions in platelets, likely due to functional overlap with other Rho GTPases. In contrast, RhoG is essential for normal granule secretion downstream of the collagen receptor GPVI. The central defect in RhoG−/− platelets is reduced dense granule secretion, which impedes integrin activation and aggregation and limits platelet recruitment to growing thrombi under shear, translating into reduced thrombus formation in vivo. Potential avenues for future work on Rho GTPases in platelets are also highlighted, including identification of the key regulator for platelet filopodia formation and investigation of the role of the many Rho GTPase regulators in platelet function in both health and disease. In platelets, Rif interacts with cytoskeleton regulators including formins mDia1 and mDia3, whereas RhoG binds SNARE-complex proteins and cytoskeletal regulators ELMO and DOCK1. Knockout mice studies suggest RhoG is essential for dense granule secretion downstream of the collagen receptor GPVI. |
| اللغة: | English |
| تدمد: | 1470-8728 0264-6021 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::8dee12c58f70730a3a55910e7d6987a6Test http://europepmc.org/articles/PMC4357237Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........8dee12c58f70730a3a55910e7d6987a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708728 02646021 |
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