المؤلفون: Wee Kiat Ong, Greg C. Smith, Gordon W. Rewcastle, Peter R. Shepherd, Weiping Han, Jackie D. Kendall

المصدر: Biochemical Journal

مصطلحات موضوعية: Male, Pyridines, medicine.medical_treatment, phosphoinositide 3-kinase catalytic α polypeptide (PIK3CA), LC-MS/MS, liquid chromatography tandem MS, Biochemistry, phosphoinositide 3-kinase (PI3K), BMR, basal metabolic rate, Eating, Mice, PI3KCA, PI3K catalytic α polypeptide, Enzyme Inhibitors, media_common, Phosphoinositide-3 Kinase Inhibitors, ATM, ataxia telangiectasia mutated, Sulfonamides, TOR Serine-Threonine Kinases, mammalian target of rapamycin (mTOR), Imidazoles, Isoenzymes, PIKK, phosphoinositide kinase-related kinase, KI, knockin, Quinolines, GTT, glucose tolerance test, PI3K, phosphoinositide 3-kinase, Research Article, Gene isoform, medicine.medical_specialty, insulin, Class I Phosphatidylinositol 3-Kinases, media_common.quotation_subject, glucose metabolism, mTOR, mammalian target of rapamycin, P110α, Biology, Carbohydrate metabolism, Motor Activity, In vivo, Internal medicine, medicine, Animals, Furans, Molecular Biology, PI3K/AKT/mTOR pathway, ITT, insulin tolerance test, PTT, pyruvate tolerance test, KO, knockout, Insulin, Hydrazones, Appetite, Cell Biology, Endocrinology, Glucose, Pyrimidines, P110δ

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820523a0345782a3ea5f0b2738bc7a43Test
http://europepmc.org/articles/PMC3343648Test

المؤلفون: Woo-Jeong Lee, Sharada Kolekar, Christina M. Buchanan, Peter R. Shepherd, Stephen M. F. Jamieson, Jack U. Flanagan, Jackie D. Kendall, William A. Denny, Ripudaman Singh, James M. J. Dickson, Bruce C. Baguley, Gordon W. Rewcastle

المصدر: Biochemical Journal

مصطلحات موضوعية: PTEN, phosphatase and tensin homologue deleted on chromosome 10, PKB, protein kinase B, medicine.medical_treatment, TGI, tumour growth inhibition, BID, twice daily dosing, p110α E545K mutation, mTOR, mammalian target of rapamycin, ERK, extracellular-signal-regulated kinase, Biochemistry, Mice, Tumor Cells, Cultured, medicine, Animals, Humans, Protein Isoforms, Tensin, PTEN, Tissue Distribution, Enzyme Inhibitors, pan-phosphoinositide 3kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235, phosphoinositide 3-kinase α (PI3Kα), Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Homeodomain Proteins, Mice, Knockout, Phosphoinositide 3-kinase, biology, QD, once daily dosing, Growth factor, PIK3CA, Neoplasms, Experimental, Cell Biology, phosphoinositide 4-kinase (PI4K), PIK3CA H1047R mutation, PI4K, phosphoinositide 4-kinase, Cell biology, Class Ia Phosphatidylinositol 3-Kinase, P110δ, biology.protein, Signal transduction, Proto-Oncogene Proteins c-akt, PI3K, phosphoinositide 3-kinase, Research Article, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1a7d1444366d807c36dc5923f61ac0Test
https://doi.org/10.1042/bj20110502Test