Molecular Cloning and Comparison of Avian Preproghrelin Genes
| العنوان: | Molecular Cloning and Comparison of Avian Preproghrelin Genes |
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| المؤلفون: | Ning Li, Jing Yuan, Xiaoxiang Hu, Jianjun Zhou |
| المصدر: | Biochemical Genetics. 45:185-194 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Signal peptide, Peptide Hormones, Molecular Sequence Data, Molecular cloning, Biology, Biochemistry, Birds, Serine, Complementary DNA, Genetics, Animals, Coding region, Amino Acid Sequence, Cloning, Molecular, Protein Precursors, Molecular Biology, Gene, Phylogeny, Ecology, Evolution, Behavior and Systematics, chemistry.chemical_classification, Base Sequence, General Medicine, Ghrelin, Amino acid, chemistry, Sequence Alignment |
| الوصف: | We report cDNA sequences for the preproghrelin gene from goose, duck, and emu. This gene is involved in stimulating the release of growth hormone in mammals and may play a similar role in avian species. The complete coding sequence of avian preproghrelin encodes a 116 amino acid (aa) protein, which is organized into three parts: the N-terminal hydrophobic signal peptide, a 26 aa peptide for mature ghrelin, and a long C-terminal polypeptide. Domain/motif structures of preproghrelin protein are highly conserved among avian species. Although the avian and mammalian homologs are not highly similar for the whole 116 aa sequence, the identity of the highly conserved "active core" sequence and the n-octanoyl modification of the serine 3 residue avian ghrelin protein with its mammalian homologs implies conserved function of ghrelin protein during evolution. Information provided in this study will be useful in further studies to determine the role the preproghrelin gene plays in the regulation of growth hormone release and body weight gain in avian species. |
| تدمد: | 1573-4927 0006-2928 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd02be8d75ae232b012bfae3f1b3b53Test https://doi.org/10.1007/s10528-006-9060-zTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1cd02be8d75ae232b012bfae3f1b3b53 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734927 00062928 |
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