التفاصيل البيبلوغرافية
| العنوان: |
MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4. |
| المؤلفون: |
Yan, Chao1, Yu, Jianchun1 yu_jchpumch@163.com, Liu, Yuqin2, Kang, Weiming1, Ma, Zhiqiang1, Zhou, Li1 |
| المصدر: |
Biochemical & Biophysical Research Communications. Nov2015, Vol. 467 Issue 4, p913-920. 8p. |
| مصطلحات موضوعية: |
*MICRORNA, *NEOPLASTIC cell transformation, *KRUPPEL-like factors, *STOMACH cancer, *COMPARATIVE studies, *CANCER prevention |
| مستخلص: |
Gastric cancer (GC) is a prevalent malignant cancer worldwide and is highly lethal because of its fast growth. Currently, the clinical therapy options for GC remain limited. MiR-32 has been reported as an oncogenic microRNA in many cancers, but its role in GC is unclear. Here, we found that miR-32 was overexpressed in GC tissues compared with adjacent normal tissue, and miR-32 was higher in GC patients' plasma compared with healthy individuals. Furthermore, we have identified miR-32 to be oncogenic, by promoting gastric cell proliferation, migration and invasion. We also identified Kruppel-like factor 4 (KLF4) as a direct target of miR-32. Knockdown of KLF4 promoted proliferation, migration and invasion of GC cells. We conclude that miR-32 promotes GC cell proliferation, migration and invasion by targeting KLF4, suggesting that the miR-32-KLF4 pathway may be useful in clinical diagnosis and therapeutics. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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