دورية أكاديمية
Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients
| العنوان: | Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients |
|---|---|
| المؤلفون: | Simachew, Yonas Mulat, Antonić, Tamara, Gojković, Tamara, Vladimirov, Sandra, Mihajlović, Marija, Vujčić, Sanja, Miloševski-Lomić, Gordana, Vekić, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Paripović, Dušan, Stefanović, Aleksandra |
| المصدر: | Biochemia Medica ; ISSN 1330-0962 (Print) ; ISSN 1846-7482 (Online) ; Volume 32 ; Issue 2 |
| سنة النشر: | 2022 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | paediatric nephrotic syndrome, glucocorticoid therapy, serum lipid profile, non-cholesterol sterols |
| الوصف: | The aim of this study was to investigate lipoprotein particle distributions and the likelihood of achieving cholesterol homeostasis in the remission phase of nephrotic syndrome (NS) in paediatric patients. We hypothesized that lipoprotein particle distributions moved toward less atherogenic profile and that cholesterol homeostasis was achieved. Thirty-three children, 2 to 9 years old with NS were recruited. Blood sampling took place both in the acute phase and during remission. Serum low-density lipoprotein particles (LDL) and high-density lipoprotein particles (HDL) were separated using non-denaturing polyacrylamide gradient gel (3-31%) electrophoresis. Serum non-cholesterols sterols (NCSs), desmosterol, lathosterol, 7-dehydrocholesterol (7-DHC), campesterol and β-sitosterol were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). All patients had desirable serum HDL cholesterol concentrations during remission. The dominant lipoprotein diameters and LDL subclass distribution did not change significantly during follow-up. In contrast, HDL lipoprotein particle distribution shifted towards larger particles. The absolute concentration of desmosterol was significantly lower during remission (P = 0.023). β-sitosterol concentration markedly increased during remission (P = 0.005). Desmosterol/β-sitosterol (P < 0.001) and 7-DHC/β-sitosterol (P = 0.005) ratios significantly declined during disease remission. Favourable changes in the serum lipid profiles, HDL particle subclass distribution and cholesterol metabolism in paediatric patients with NS during remission took place. For the first time, we found that cholesterol homeostasis changed in favour of increased cholesterol absorption during disease remission. Nevertheless, complete cholesterol homeostasis was not achieved during disease remission. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://hrcak.srce.hr/279450Test |
| الإتاحة: | https://doi.org/10.11613/BM.2022.020706Test https://hrcak.srce.hr/279450Test https://hrcak.srce.hr/file/404789Test |
| حقوق: | info:eu-repo/semantics/openAccess ; Biochemia Medica is open access journal and all published articles are subject to CC-BY Creative Commons Attribution Licence which permits users to read, download, copy, distribute, print, search, or link to the full texts of these articles in any medium or format. Manuscript submission, article processing and publishing is free of charge and all copyrights to the manuscript are transferred to Biochemia Medica. The publisher (Croatian Society of Medical Biochemistry and Laboratory Medicine) has the right to reproduce and distribute the article in printed and electronic form. Journal is maintained and published with the financial support of the members of the Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM) and grants given by the Republic of Croatia’s Ministry of Science and Education. All Editorial work and peer-review are maintained voluntarily. Occasionally, Biochemia Medica may publish a promotional material and advertisement in order to promote sponsorship with emphasis on the special subjects from the field of Laboratory Medicine. |
| رقم الانضمام: | edsbas.733DB4CE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |