دورية أكاديمية
Effect of bisphosphonates on bone giant cell tumor recurrence: a meta-analysis
| العنوان: | Effect of bisphosphonates on bone giant cell tumor recurrence: a meta-analysis |
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| المؤلفون: | Marwa Mohsen, Hasnaa Osama, Mina Nicola, Haitham Saeed, Mohamed E. A. Abdelrahim |
| المصدر: | Beni-Suef University Journal of Basic and Applied Sciences, Vol 11, Iss 1, Pp 1-8 (2022) |
| بيانات النشر: | SpringerOpen, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Science |
| مصطلحات موضوعية: | Giant cell tumor of bone, Bisphosphonates, Recurrence, Intralesional curettage, Wide resection, Medicine (General), R5-920, Science |
| الوصف: | Abstract Background We examined the impact of bisphosphonates as adjuvant therapy on the recurrence of giant cell bone tumors and the impact of various tumor stages and surgical techniques on this effect. Following a thorough examination of the literature up to January 2022, 10 studies including 601 adults with giant cell tumors of the bone were reported; 295 of these subjects received bisphosphonates as adjuvant therapy following surgery, and 306 served as the control group. To examine the possibility of lowering the recurrence of giant cell bone tumors, a comparison between bisphosphonates and a control group was made. In order to evaluate the impact of bisphosphonates as adjuvant therapy on the recurrence of the giant cell bone tumor, odds ratios (OR) with 95% confidence intervals (CIs) were determined. Additionally, the dichotomous technique with a random or fixed-effect model was used to examine the effects of various tumor stages and pertinent surgical procedures. Results Patients with giant cell tumors of the bone who received bisphosphonates as adjuvant therapy had significantly lower postoperative recurrence rates outcomes in all subjects with giant cell tumor of bone (OR 0.19; 95% CI 0.12–0.31, p = 0.001), patients with stage I–II giant cell tumors of the bone (OR 0.29; 95% CI 0.11–0.76, p = 0.01), patients with stage III giant cell tumors of the bone (OR 0.17; 95% CI 0.07–0.42, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-8543 40407535 |
| العلاقة: | https://doaj.org/toc/2314-8543Test |
| DOI: | 10.1186/s43088-022-00292-2 |
| الوصول الحر: | https://doaj.org/article/d7ef404075354eeea913fab884510665Test |
| رقم الانضمام: | edsdoj.7ef404075354eeea913fab884510665 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23148543 40407535 |
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| DOI: | 10.1186/s43088-022-00292-2 |