The gut mycobiome composition is linked to carotid atherosclerosis
| العنوان: | The gut mycobiome composition is linked to carotid atherosclerosis |
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| المؤلفون: | J. Lozano-Bartolomé, M. Mar Rodríguez, Felipe J. Chaves, José Manuel Fernández-Real, Matilde R. Chacón, Wifredo Ricart, Gemma Xifra, J. Puig, Gerard Blasco, Manuel Portero-Otin |
| المصدر: | Beneficial Microbes r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Adult, Carotid Artery Diseases, Mycobiota, Physiology, Biology, Microbiology, Carotid Intima-Media Thickness, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, DNA, Ribosomal Spacer, medicine, Humans, Obesity, Mucor, Gastrointestinal tract, Framingham Risk Score, Mucor racemosus, Fungi, Anatomy, Middle Aged, medicine.disease, biology.organism_classification, Gastrointestinal Tract, 030104 developmental biology, 030220 oncology & carcinogenesis, Composition (visual arts), Female, Genome, Fungal, Mycobiome, Biomarkers |
| الوصف: | The mycobiotic component of the microbiota comprises an integral, yet under-researched, part of the gastrointestinal tract. Here, we present a preliminary study of the possible contribution of gut mycobiota to sub-clinical atherosclerosis in a well-characterised group of obese and non-obese subjects in association with the Framingham Risk Score (FRS) and carotid intima-media thickness (cIMT). From all taxa identified, the relative abundance of the phylum Zygomycota, comprising the family Mucoraceae and genus Mucor, was negatively associated with cIMT and this association remained significant after controlling for false discovery rate. Obese subjects with detectable Mucor spp. had a similar cardiovascular risk profile as non-obese subjects. Interestingly, the relative abundance of Mucor racemosus was negatively associated both with FRS and cIMT. Partial least square discriminant analyses modelling, evaluating the potential relevance of gut mycobiota in patients stratified by mean values of cIMT, showed that even a 1 component model had a high accuracy (0.789), with a high R2 value (0.51). Variable importance in projection scores showed that M. racemosus abundance had the same impact in the model as waist-to-hip ratio, high-density lipoprotein-cholesterol, fasting triglycerides or fasting glucose, suggesting that M. racemosus relative abundance in the gut may be a relevant biomarker for cardiovascular risk. |
| تدمد: | 1876-2891 1876-2883 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4728fc88005ae4cb2bc4c264824badf6Test https://pubmed.ncbi.nlm.nih.gov/29124969Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4728fc88005ae4cb2bc4c264824badf6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18762891 18762883 |
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