Forced exercise activates the NrF2 pathway in the striatum and ameliorates motor and behavioral manifestations of Parkinson's disease in rotenone-treated rats
| العنوان: | Forced exercise activates the NrF2 pathway in the striatum and ameliorates motor and behavioral manifestations of Parkinson's disease in rotenone-treated rats |
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| المؤلفون: | Omyma Galal Ahmed, Dina M. Monir, Amany Abdelrahman, Motamed Elsayed Mahmoud, Ibrahim F. Rehan |
| المصدر: | Behavioral and Brain Functions, Vol 16, Iss 1, Pp 1-12 (2020) Behavioral and Brain Functions : BBF |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Neurology, Parkinson's disease, Behavioral tests, Striatum, lcsh:RC346-429, Antiparkinson Agents, Levodopa, Behavioral Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Parkinson, Treadmill, 0303 health sciences, Movement Disorders, Behavior, Animal, Dopaminergic, General Medicine, Up-Regulation, Motor coordination, Memory, Short-Term, Signal Transduction, medicine.drug, medicine.medical_specialty, Tyrosine 3-Monooxygenase, NF-E2-Related Factor 2, Cognitive Neuroscience, 03 medical and health sciences, Dopamine, Physical Conditioning, Animal, Internal medicine, Rotenone, medicine, Animals, Parkinson Disease, Secondary, Rats, Wistar, Exercise, Gait Disorders, Neurologic, Biological Psychiatry, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, Uncoupling Agents, business.industry, Research, Nrf2. TFAM, medicine.disease, Rats, Neostriatum, Endocrinology, chemistry, business, Noq1, Psychomotor Performance, 030217 neurology & neurosurgery |
| الوصف: | Background Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions, and cognition. While the pathogenesis of PD is not clear, damage of dopaminergic neurons by oxygen-derived free radicals is considered an important contributing mechanism. This study aimed to evaluate the role of treadmill exercise in male Wister rats as a single treatment and as an aid-therapy with L-dopa for rotenone-induced PD. To study the role of the Nrf2- ARE pathway as a mechanism involved in exercise-associated improvement in rotenone-induced PD in rats. Method Animals were divided into 5 groups, (Control, rotenone, rotenone\exercise, rotenone\L-dopa, and rotenone\exercise\L-dopa (combination)groups). After the PD induction, rats in the rotenone\exercise and combination groups were daily treadmill exercised for 4 weeks. Results Treadmill exercise significantly improved behavioral and motor aspects of rotenone-induced PD. When treadmill exercise was introduced as a single intervention, it amended most behavioral aspects of PD, gait fully corrected, short-term memory, and motor coordination. Where L-dopa corrected locomotor activity and motor coordination but failed to improve short-term memory and only partially corrected the gait of rotenone-treated rats. When treadmill exercise was combined with L-dopa, all features of PD were corrected. It was found that exercise upregulated some of its associative genes to Nrf2 pathways such as TFAM, Nrf2 and NQO.1 mRNA expression. Conclusion This study suggests that forced exercise improved parkinsonian like features by activating the Nrf2 pathway. |
| اللغة: | English |
| تدمد: | 1744-9081 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550dda6a1f1f386a91b63e1605f92a40Test http://link.springer.com/article/10.1186/s12993-020-00171-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....550dda6a1f1f386a91b63e1605f92a40 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17449081 |
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