دورية أكاديمية
Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas
| العنوان: | Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas |
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| المؤلفون: | İrfan Cicin, Tahsin Özatlı, Esma Türkmen, Türkan Özturk, Melike Özçelik, Devrim Çabuk, Ayşe Gökdurnalı, Özlem Balvan, Yaşar Yıldız, Metin Şeker, Nuriye Özdemir, Burcu Yapar, Özgür Tanrıverdi, Yusuf Günaydin, Serkan Menekşe, Berna Öksüzoğlu, Asude Aksoy, Bülent Erdoğan, M. Bekir Hacıoglu, Erkan Arpaci, Alper Sevinç, Mehmet Atilla Uysal, Sinem İliaz |
| المصدر: | Balkan Medical Journal, Vol 33, Iss 5, Pp 517-524 (2016) |
| بيانات النشر: | Galenos Publishing House |
| سنة النشر: | 2016 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Carcinosarcoma, ovary, uterine, predictive factors, prognostic factors, Medicine |
| الوصف: | Background: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT. Aims: We aimed to define the prognostic and predictive factors associated with treatment options in ovarian (OCS) and uterine carcinosarcoma (UCS). Study Design: Retrospective cross-sectional study Methods: We retrospectively reviewed the medical records of patients with ovarian and uterine carcinosarcoma from 2000 to 2013, and 127 women were included in this study (24 ovarian and 103 uterine). Patients admitted to seventeen oncology centres in Turkey between 2000 and December 2013 with a histologically proven diagnosis of uterine carcinosarcoma with FIGO 2009 stage I-III and patients with sufficient data obtained from well-kept medical records were included in this study. Stage IV tumours were excluded. The patient records were retrospectively reviewed. Data from 104 patients were evaluated for this study. Results: Age (≥70 years) was a poor prognostic factor for UCS (p=0.036). Pelvic±para aortic lymph node dissection did not affect overall survival (OS) (p=0.35). Macroscopic residual disease was related with OS (p<0.01). The median OS was significantly longer in stage I-II patients than stage III patients (p=0.03). Adjuvant treatment improved OS (p=0.013). Adjuvant radiotherapy tended to increase the median OS (p=0.075). However, this tendency was observed in UCS (p=0.08) rather than OCS (p=0.6).Adjuvant chemotherapy had no effect on OS (p=0.15).Adjuvant radiotherapy significantly prolonged the median OS in patients with endometrioid component (p=0.034). A serous/clear cell component was a negative prognostic ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2146-3123 2146-3131 |
| العلاقة: | http://balkanmedicaljournal.org/text.php?lang=en&id=29Test; https://doaj.org/toc/2146-3123Test; https://doaj.org/toc/2146-3131Test; https://doaj.org/article/a941accd41ad4cb09b80b59a161a3f2cTest |
| DOI: | 10.5152/balkanmedj.2016.151268 |
| الإتاحة: | https://doi.org/10.5152/balkanmedj.2016.151268Test https://doaj.org/article/a941accd41ad4cb09b80b59a161a3f2cTest |
| رقم الانضمام: | edsbas.CA85EB78 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21463123 21463131 |
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| DOI: | 10.5152/balkanmedj.2016.151268 |