Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma
| العنوان: | Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma |
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| المؤلفون: | Yuan Ling Liu, Pei Ming Yang, Ching-Chow Chen, Chia-Tung Shun, Jing Ru Weng, Ming-Shiang Wu |
| المصدر: | Autophagy. 6:1057-1065 |
| بيانات النشر: | Informa UK Limited, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Programmed cell death, Carcinoma, Hepatocellular, medicine.drug_class, ATG5, Antineoplastic Agents, Apoptosis, Biology, Endoplasmic Reticulum, Hydroxamic Acids, Mice, Phosphatidylinositol 3-Kinases, Stress, Physiological, Cell Line, Tumor, Phagosomes, Autophagy, medicine, Animals, Humans, Molecular Biology, Vorinostat, Adenine, TOR Serine-Threonine Kinases, Liver Neoplasms, Histone deacetylase inhibitor, Cancer, Drug Synergism, Cell Biology, medicine.disease, Histone Deacetylase Inhibitors, Cancer cell, Cancer research, Macrolides, Histone deacetylase, Drug Screening Assays, Antitumor, Microtubule-Associated Proteins, Proto-Oncogene Proteins c-akt, Signal Transduction, medicine.drug |
| الوصف: | Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death worldwide. Drug treatments for HCC have been largely unsuccessful. Histone deacetylase inhibitors can reactivate tumor suppressor genes in cancer cells and serve as potential anti-cancer drugs. Two potent HDAC inhibitors OSU-HDAC42 and SAHA induced autophagy in HCC cells as revealed by transmission electron microscopy, immunofluorescence and LC3-II accumulation. We found that SAHA and OSU-HDAC42 induced autophagy through downregulation of Akt/mTOR signaling and induction of ER stress response. Inhibition of autophagy by 3-MA or Atg5 knockout reduced SAHA-induced cytotoxicity, indicating that SAHA-induced autophagy led to cell death. Our results show that the combination of autophagy inducers with SAHA might be attractive for the treatment of HCC and pharmacological targeting of autophagy provides promise for the management of cancer therapy. |
| تدمد: | 1554-8635 1554-8627 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5575ac6281f2477a4645230171ba86Test https://doi.org/10.4161/auto.6.8.13365Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a5575ac6281f2477a4645230171ba86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15548635 15548627 |
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