التفاصيل البيبلوغرافية
| العنوان: |
Circulating CXCL10 is increased in non-segmental vitiligo, in presence or absence of autoimmune thyroiditis. |
| المؤلفون: |
Ferrari, Silvia Martina1, Fallahi, Poupak1, Santaguida, Giulia2, Virili, Camilla2, Ruffilli, Ilaria1, Ragusa, Francesca1, Centanni, Marco2, Antonelli, Alessandro1 alessandro.antonelli@med.unipi.it |
| المصدر: |
Autoimmunity Reviews. Sep2017, Vol. 16 Issue 9, p946-950. 5p. |
| مصطلحات موضوعية: |
*VITILIGO, *AUTOIMMUNE thyroiditis, *THYROIDITIS, *CHEMOKINES, *BLOOD serum analysis |
| مستخلص: |
Recently the importance of CXCL10 in the pathogenesis of non-segmental vitiligo (NSV) and autoimmune thyroid disorders (AITD) has been shown. No data are present about chemokines CXCL10 (Th1 prototype) and CCL2 (Th2 prototype) circulating levels in NSV patients with/without thyroiditis (AT). Serum CXCL10 and CCL2 have been measured in 50 consecutive NSV patients, in 40 consecutive patients with NSV and AT (NSV + AT), in 50 sex- and age-matched controls without AT (control 1) and in 40 sex- and age-matched patients with AT without NSV (control 2). Serum CXCL10 levels were significantly higher in control 2, than in control 1 ( P = 0.001; ANOVA). NSV patients have serum CXCL10 levels significantly higher than control 1, or control 2 ( P = 0.001). NSV + AT patients have serum CXCL10 levels higher than control 1, or 2 ( P < 0.001), and than NSV ( P = 0.01). In conclusion, we first demonstrate high serum CXCL10 in NSV patients, overall in presence of AT and hypothyroidism, suggesting the importance of a common Th1 immune response in their immune-pathogenesis. To evaluate if serum CXCL10 might be used as a clinical marker of NSV and/or AT further studies are needed. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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