التفاصيل البيبلوغرافية
| العنوان: |
The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms |
| المؤلفون: |
Leete, Pia, Mallone, Roberto, Richardson, Sarah J., Sosenko, Jay M., Redondo, Maria J., Evans-Molina, Carmella |
| المساهمون: |
Medicine, School of Medicine |
| المصدر: |
Author |
| بيانات النشر: |
Springer |
| سنة النشر: |
2018 |
| المجموعة: |
Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: |
type 1 diabetes, age, C-peptide |
| الوصف: |
Purpose of Review To explore the impact of age on type 1 diabetes (T1D) pathogenesis. Recent Findings Children progress more rapidly from autoantibody positivity to T1D and have lower C-peptide levels compared to adults. In histological analysis of post-mortem pancreata, younger age of diagnosis is associated with reduced numbers of insulin containing islets and a hyper-immune CD20hi infiltrate. Moreover compared to adults, children exhibit decreased immune regulatory function and increased engagement and trafficking of autoreactive CD8+ T cells, and age-related differences in β cell vulnerability may also contribute to the more aggressive immune phenotype observed in children. To account for some of these differences, HLA and non-HLA genetic loci that influence multiple disease characteristics, including age of onset, are being increasingly characterized. Summary The exception of T1D as an autoimmune disease more prevalent in children than adults results from a combination of immune, metabolic, and genetic factors. Age-related differences in T1D pathology have important implications for better tailoring of immunotherapies. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Current Diabetes Reports; Leete, P., Mallone, R., Richardson, S. J., Sosenko, J. M., Redondo, M. J., & Evans-Molina, C. (2018). The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms. Current Diabetes Reports, 18(11), 115. https://doi.org/10.1007/s11892-018-1083-4Test; https://hdl.handle.net/1805/19604Test |
| الإتاحة: |
https://hdl.handle.net/1805/19604Test |
| حقوق: |
Publisher Policy |
| رقم الانضمام: |
edsbas.4998C89B |
| قاعدة البيانات: |
BASE |
