التفاصيل البيبلوغرافية
| العنوان: |
Time from diagnosis of type 2 diabetes to initiation of insulin therapy is related to carotid artery intima-media thickness |
| المؤلفون: |
Zheng, Ling1, Buchanan, Thomas A.2, Hodis, Howard N.1,2,3, Li, Yanjie3, Torres, Mina1, Mack, Wendy J.1,3 wmack@usc.edu |
| المصدر: |
Atherosclerosis (00219150). Oct2003, Vol. 170 Issue 2, p293. 7p. |
| مصطلحات موضوعية: |
*TYPE 2 diabetes diagnosis, *INSULIN, *ULTRASONIC imaging, *CAROTID artery |
| مستخلص: |
To investigate the association between time from diagnosis of type 2 diabetes to initiation of insulin therapy (pre-exogenous insulin period) and intima-media thickness (IMT) of the common carotid artery (CCA), a cross-sectional analysis was conducted among 98 males and 193 females (90% Hispanic) with type 2 diabetes, aged 30–70 years old. The association between the pre-exogenous insulin period and the primary outcome was examined in men and women using analysis of covariance (ANCOVA) with adjustment for current age, duration of insulin therapy, low-density lipoprotein (LDL) cholesterol, systolic blood pressure and hemoglobin A1c. The pre-exogenous insulin period was significantly and linearly associated with mean IMT of the CCA in men. In women, the linear trend was not significant while a significant quadratic trend was noted across three categories of the pre-exogenous insulin period (0–5, 6–10, 11–24 years). Longitudinal data are needed to determine the effect of early initiation of insulin therapy on the progression of subclinical atherosclerosis among persons with diabetes. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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