التفاصيل البيبلوغرافية
| العنوان: |
Circulating vaspin levels and epicardial adipose tissue thickness are associated with impaired coronary flow reserve in patients with nonalcoholic fatty liver disease |
| المؤلفون: |
Yilmaz, Yusuf1,2 yusufyilmaz@uludag.edu.tr, Kurt, Ramazan1,2, Gurdal, Ahmet3, Alahdab, Yesim Ozen1, Yonal, Oya1, Senates, Ebubekir4, Polat, Nihat3, Eren, Fatih2, Imeryuz, Nese1,2, Oflaz, Huseyin3 |
| المصدر: |
Atherosclerosis (00219150). Jul2011, Vol. 217 Issue 1, p125-129. 5p. |
| مصطلحات موضوعية: |
*ADIPOSE tissues, *FATTY liver, *CORONARY arteries, *BLOOD flow, *BIOMARKERS, *CYTOKINES |
| مستخلص: |
Abstract: Background: Patients with nonalcoholic fatty liver disease (NAFLD) have a reduced coronary flow reserve (CFR) and an increased risk of cardiovascular disease. The fat cells that surround coronary arteries may play a central and underrecognized role in development of cardiovascular disease through the systemic secretion of adipokines. We therefore evaluated the relation of epicardial fat thickness, serum levels of epicardial fat-related adipokines (chemerin and vaspin), and CFR in patients with NAFLD. Methods: We investigated 54 patients with biopsy-proven NAFLD and 56 age- and sex-matched controls. CFR and epicardial fat thickness (EFT) were measured by transthoracic echocardiography. Serum levels of chemerin and vaspin were measured by ELISA. Results: EFT was significantly higher (0.64±0.13 vs. 0.54±0.10cm, P <0.001) and CFR significantly lower (2.11±0.45 vs. 2.52±0.62, P <0.001) in patients with NAFLD than in controls. Serum levels of vaspin and chemerin were both significantly increased in patients with NAFLD compared with controls. Stepwise regression analysis showed that EFT (β =−0.53, t =−3.7, P <0.001), serum vaspin levels (β =−0.30, t =−2.5, P =0.014), and liver fibrosis (β =−0.31, t =−2.11, P =0.041), in the order they entered into the model, were independent predictors of CFR in NAFLD patients. Conclusion: Our data suggest the presence of a complex interplay between EFT, serum vaspin, and liver histology in promoting an impaired hyperemic stimulation of coronary blood flow in patients with NAFLD. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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