التفاصيل البيبلوغرافية
| العنوان: |
Elevated levels of plasma prekallikrein, high molecular weight kininogen and factor XI in coronary heart disease |
| المؤلفون: |
Merlo, Christoph1, Wuillemin, Walter A.1,2 walter.wuillemin@ksl.ch, Redondo, Maurice1, Furlan, Miha1, Sulzer, Irmela1, Kremer-Hovinga, Johanna1, Binder, Bernd R.3, Lämmle, Bernhard1 |
| المصدر: |
Atherosclerosis (00219150). Apr2002, Vol. 161 Issue 2, p261. 7p. |
| مصطلحات موضوعية: |
*MYOCARDIAL infarction, *HEMOSTASIS |
| مستخلص: |
Increased levels of hemostatic factors may play a role in the pathogenesis of myocardial infarction by triggering thrombin formation. We measured factor XII (FXII), factor XI (FXI), plasma prekallikrein (PK) and high-molecular-weight kininogen (HK) in 200 patients having survived myocardial infarction for at least 2 months, and in 100 healthy controls. We found significantly elevated levels of FXI clotting activity (FXI:C), HK:C and of the amidolytic activity of PK (PK:Am) among the patients as compared to the controls. Plasma levels of FXI:C, HK:C and PK:Am in the highest quartile were associated with an odds ratio of 1.9 (95% CI: 1.0–3.8), 2.0 (95% CI: 1.0–4.0) and 5.4 (95% CI: 2.6–11.2), respectively, compared to the respective plasma levels in the lowest quartile. After correction for established clinical and laboratory risk factors, the association between PK:Am plasma levels and myocardial infarction remained significant (P=0.0007). Combination of high PK:Am plasma levels and smoking or arterial hypertension, respectively, resulted in a more than additive relative risk for myocardial infarction. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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