التفاصيل البيبلوغرافية
| العنوان: |
Serum vaspin levels are positively associated with carotid atherosclerosis in a general population. |
| المؤلفون: |
Esaki, Eishi1, Adachi, Hisashi1,2 hadac@med.kurume-u.ac.jp, Hirai, Yuji1, Yamagishi, Sho-ichi3, Kakuma, Tatsuyuki4, Enomoto, Mika1, Fukami, Ako1, Kumagai, Eita1, Ohbu, Kyoko1, Obuchi, Aya1, Yoshimura, Ayako1, Nakamura, Sachiko1, Nohara, Yume1, Fujiyama, Tomoki1, Fukumoto, Yoshihiro1, Imaizumi, Tsutomu5 |
| المصدر: |
Atherosclerosis (00219150). Mar2014, Vol. 233 Issue 1, p248-252. 5p. |
| مصطلحات موضوعية: |
*ADIPOKINES, *ATHEROSCLEROSIS, *SERUM, *INSULIN resistance, *CAROTID intima-media thickness, *CRASH test dummies, *ULTRASONIC imaging, *REGRESSION analysis |
| مستخلص: |
Abstract: Objectives: Vaspin is a novel adipocytokine with potential insulin-sensitizing properties. Insulin resistance (IR) plays a role in the development and progression of atherosclerosis. However, the relationship between serum vaspin levels and atherosclerosis remains unknown. Therefore, we investigated whether vaspin was correlated with carotid intima-media thickness (c-IMT). Methods: Data for fasting vaspin levels of 201 subjects (78 men and 123 women aged over 40 years) were obtained from a general population in Japan. We obtained anthropometric parameters and blood chemistries, and calculated homeostasis model assessment-IR (HOMA-IR) index. C-IMT was measured by B-mode ultrasonography. The mean values of each parameter by tertiles of vaspin were compared with analysis of variance, and the associations of vaspin with IR and c-IMT were evaluated by multiple stepwise regression analysis. Results: Univariate analysis revealed that vaspin levels were positively correlated with BMI, insulin, HOMA-IR index, estimated glomerular filtration rate (eGFR), c-IMT and hypertensive medication. Multiple stepwise regression analysis revealed that HOMA-IR index, c-IMT and eGFR were significantly and independently associated with vaspin. We performed multivariate analyses with c-IMT as the dependent variable. Age, hypertensive medication and vaspin were significant for c-IMT. Moreover, a mediation analysis demonstrated that vaspin was significantly related to c-IMT, independently of IR. Conclusions: The present study not only confirmed the previous finding of the positive association of vaspin with IR but also demonstrated that serum vaspin level was positively associated with c-IMT, independently of IR in a general population. Our results may suggest a role of vaspin in atherosclerosis in humans. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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