THE ANTIDEPRESSANT DRUG DOXEPIN: A PROMISING ANTIOXIDANT
| العنوان: | THE ANTIDEPRESSANT DRUG DOXEPIN: A PROMISING ANTIOXIDANT |
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| المؤلفون: | Debanjan Mukhopadhyay, Sukhen Das, Shauroseni Palchoudhuri, Bidisha Ghosh, Sujata G. Dastidar, Debalina Sinha Roy |
| المصدر: | Asian Journal of Pharmaceutical and Clinical Research. 10:97 |
| بيانات النشر: | Innovare Academic Sciences Pvt Ltd, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Pharmacology, chemistry.chemical_classification, Antioxidant, Chemistry, medicine.medical_treatment, 05 social sciences, Flavonoid, Pharmaceutical Science, Doxepin, Chelating Activity, Ferrous, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0502 economics and business, medicine, Ferric, Pharmacology (medical), Quercetin, Hydrogen peroxide, 050203 business & management, medicine.drug |
| الوصف: | Objective: Oxidative stress contributes to the pathophysiology of exposure to environmental pollutants and to different free radical generatingbiochemical reactions in a human system leading to various types of age-related ailments. An antioxidant is a substance capable of preventingor slowing down oxidation of other molecules. Administration of different natural or synthetic antioxidants can ably lead to prevention andattenuation of such stress-induced biochemical alterations. Best examples of natural antioxidants are plant-derived flavonoids. The presentstudy has been designated to determine antioxidant properties in antidepressant compound doxepin which is structurally similar to flavonoidquercetin.Methods: Antioxidant capacity in doxepin was determined with help of several standard conventional procedures such as phosphomolybdenumassay, Ferric ion and cupric ion reducing power assays, ferrous ion chelating activity assay, hydrogen peroxide, and nitric oxide scavenging activityassays.Results: Doxepin showed a stable rise in its antioxidant activity in a dose-dependent manner as determined by ferric as well as cupric ion reducingcapacity and by phosphomolybdenum assay. An almost identical observation was noted while determining ferrous ion chelating activity. Furthermore,doxepin showed a strong nitric oxide scavenging activity in all the concentrations used in the study while its hydrogen peroxide scavenging activitywas only observed at 500 μg/ml of doxepin.Conclusion: Thus, our study opens up a new vista in search for antioxidants not only from plant sources but also from clinically establishedpharmaceutical compounds that are already in practical use among patients.Keywords: Antioxidant, Antidepressant, Doxepin, Quercetin, Flavanol, Flavonoids. |
| تدمد: | 2455-3891 0974-2441 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::a0514226f856bd87a2bddf7d4bb01d6dTest https://doi.org/10.22159/ajpcr.2017.v10i3.15149Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........a0514226f856bd87a2bddf7d4bb01d6d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24553891 09742441 |
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